objective: plasmodium falciparum chloroquine resistance is a major problem in malaria endemic areas. single nucleotide polymorphisms in pfcrt and pfmdr1 genes are known to be associated with chloroquine resistance in some parts of the world. the major goal of the present study was to detect the five single nucleotide polymorphisms in pfmdr1 gene and one single nucleotide polymorphisms in pfcrt ...

 Abstract Background: Hypoglycaemia is a well recognized complication of falciparum malaria in children but its diagnosis may be overlooked because all the clinical features may be mimicked by severe malaria. To determine the prevalence of hypoglycaemia at the point of hospital admission of under-fives with falciparum malaria and identify its risk factors in patients seen in a Nigerian...

Abstract Background Malaria is an acute and chronic illness characterized by paroxysms of fever, chills, sweating, fatigue, anemia, and splenomegaly. Most malarial deaths occur in infants and young children.Anemia in malaria has diverse pathophysiologic mechanisms such as direct invasion of Red cells, In the following, we presented comparison of hematological aspects: children with Malaria an...

Plasmodium falciparum (P. falciparum) is the main parasite known to cause malaria in humans. The antimalarial drug atovaquone inhibit Qo-site of cytochrome bc1 complex P. falciparum, which ultimately blocks ATP synthesis, leading cell death. Through years, mutations complex, causing resistance atovaquone, have emerged. present investigation applies molecular dynamics (MD) simulations study how ...

background genetic diversity has provided plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites. merozoite surface protein-3 (msp-3) has been used to develop vaccines and investigate the genetic diversity regarding p. falciparum malaria in iran. objectives the main goal of this study...

background: aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. this study investigated some new aurones derivatives against chloroquine sensitive plasmodium falciparum. here we report the synthesis , in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2...

the children aged under 5 years from vast african areas badly suffer from falciparum malaria and many of them die of this disease. therapeutic efficacy of anti-malaria drugs, especially pyrimethamine-sulfadoxine (ps) and chloroquine (cq) to falciparum malaria is frequently evaluated and reported in recent 10 years. unfortunately, to date, these widespread materials and researches have not been ...