amelogenesis imperfecta (ai) is a disorder of tooth development where there is an abnormal formation of enamel or the external layer of teeth. the aim of this study was to screen mutations in the four most important candidate genes, enam, klk4, mmp20 and fam83h responsible for amelogenesis imperfect.geneomic dna was isolated from five iranian families with 22 members affected with enamel malfor...

amelogenesis imperfectas (ais) are clinically and genetically heterogeneous conditions characterized by a wide range of clinical features. these abnormalities of enamel formation are categorized into three main groups, hypoplastic, hypomaturation and hypocalcified with different modes of inheritance such as autosomal recessive (ar), autosomal dominant (ad) and x-lined recessive (xlr). in spite ...

The domestic dog (Canis familiaris) segregates more naturally-occurring diseases and phenotypic variation than any other species and has become established as an unparalled model with which to study the genetics of inherited traits. We used a genome-wide association study (GWAS) and targeted resequencing of DNA from just five dogs to simultaneously map and identify mutations for two distinct in...

Amelogenesis Imperfectas (AIs) are clinically and genetically heterogeneous conditions characterized by a wide range of clinical features. These abnormalities of enamel formation are categorized into three main groups, hypoplastic, hypomaturation and hypocalcified with different modes of inheritance such as autosomal recessive (AR), autosomal dominant (AD) and X-lined recessive (XLR). In spite ...