Family history information is often incomplete in population-based disease registers because of truncation and/or missing family links. In this study, the authors simulated complete populations of related individuals with realistic age, family structure, and incidence rates. After mimicking the realities of register-based data, such as left truncation of family history and missing family links ...

This research analyzes the prevalence of metabolic syndrome (MS) in Korea and examines how the presence of a familial history of diseases related to MS, such as hypertension/stroke, cardiovascular disease, and diabetes, affect the development of MS in Koreans. The prevalence of MS and its components, as defined by the Nation-al Cholesterol Education Program Adult Treatment Panel guidelines, wer...

pachydermodactyfy is a rare, benign mostly asymptomatic digital fibromatosis, characterized by swelling on the back and sides of proximal phalanges and (or) proximal interphaiangeal joints. it occurs predominantly in young males although a few women including a familial case were recently described. a history of repeated trauma is sometimes available, but the etiology remains unknown. we report...

BACKGROUND/AIM Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-κΒ) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background. MATERIALS AND METHODS Four groups of patients were formed depe...

PURPOSE An overwhelming majority of data on familial risk in cancer is based on incident cancer, whereas familiality in cancer mortality is largely unknown. If fatal form of cancer was a highly familial subtype, then familial risk for mortality may exceed that of incidence, which would be particularly relevant for clinical decision making and counseling. PATIENTS AND METHODS The individuals i...

BACKGROUND The purpose of this study is to follow the familial incidence of non-syndromic or isolated cleft lip, with or without cleft palate (NSCL/P), and to analyze the relationships between the type of NSCL/P in the affected individual and his/her parent, looking at children in the first grade. MATERIAL AND METHODS To investigate the familial incidence of NSCL/P we analyzed the records of ...

congenitally missing of maxillary lateral incisors is one of the most common patterns of hypodontia. this paper presents a nine year old boy with congenital missing of lateral incisors. familial history showed that, his mother, aunts, uncle and grandmother have also congenital absence of lateral incisors.

AIMS Age-related macular degeneration (AMD) is a multifactorial disease, in which complement-mediated inflammation plays a pivotal role. A positive family history is an important risk factor for developing AMD. Certain lifestyle factors are shown to be significantly associated with AMD in non-familial cases, but not in familial cases. This study aimed to investigate whether the contribution of ...