Nuclear pore complexes (NPCs) gate the only conduits for nucleocytoplasmic transport in eukaryotes. Their gate is formed by nucleoporins containing large intrinsically disordered domains with multiple phenylalanine-glycine repeats (FG domains). In combination, these are hypothesized to form a structurally and chemically homogeneous network of random coils at the NPC center, which sorts macromol...

A numerical procedure for the design of impact damage resistant composite laminated structures is proposed in the present paper. This procedure, based on probabilistic analyses, is able to support the design of complex composite laminated structures by accounting for the scatter in composite materials’ mechanical properties (related to the mutable environmental conditions experienced by an airc...

Similar to the very vast prior literature on analyzing laminated composite structures, “higher-order” and “layer-wise higher-order” plate and shell theories for functionally-graded (FG) materials and structures are also widely popularized in the literature of the past two decades. However, such higher-order theories involve (1) postulating very complex assumptions for plate/shell kinematics in ...

Distributed sensing of structural states is essential to vibration control, health monitoring and shape control of precision structronic systems. Paraboloidal shells of revolution are widely used in aerospace, telecommunication, etc. structures. However, distributed sensing of paraboloidal shell structures is rarely investigated over the years. Micro-sensing characteristics, sensor segmentation...

The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography. For this purpose, beta-carbolines FG 7142 and DMCM were employed. They exert their effects via the benzodiazepine receptor, and whereas both possess anxiogenic properties, FG 7142 is a proconvulsant and DMCM a potent c...

The 62 kDa FG repeat domain of the nucleoporin Nsp1p forms a hydrogel-based, sieve-like permeability barrier that excludes inert macromolecules but allows rapid entry of nuclear transport receptors (NTRs). We found that the N-terminal part of this domain, which is characterized by Asn-rich inter-FG spacers, forms a tough hydrogel. The C-terminal part comprises charged inter-FG spacers, shows lo...

Cobalt-based superalloys are common materials for the manufacturing of various components used in aerospace applications. Conventional cobalt-based with a unimodal grain structure generally exhibit low strength and ductility at high temperatures. A bimodal superalloy, Co–20Cr–15W–10Ni (CCWN), was designed to achieve both The deformation behavior tensile properties CCWN alloy fine-grain (FG), co...

This dissertation investigates methods for the automated design and optimization of laminated composite structures. Optimal design of laminated composite structures is challenging due to the possibility to locally adapt the material system to the mechanical situation. Automated structural design on a computer is enabled by a combination of numerical simulation and optimization algorithms. The f...

We have developed a new transparent conductor based on one-dimensional metal-dielectric photonic band gap structures. Thin-film metal-dielectric filters containing at least 150nm of silver have been fabricated, with transmittance greater than 50% over the 500-600nm waveband, and sheet resistance of ∼ 0.1 Ohm/Square. Theoretical calculations predict at least 25% transparency levels for structure...