The properties of therapeutic proteins can be enhanced by chemical modification. Methods for site-specific protein conjugation are critical to such efforts. Here, we demonstrate that recombinant proteins expressed in mammalian cells can be site-specifically modified by using a genetically encoded aldehyde tag. We introduced the peptide sequence recognized by the endoplasmic reticulum (ER)-resid...

in this paper, we introduce the concept of rarely generalized regular fuzzy continuous functions in the sense of a.p. sostak's and ramadan is introduced. some interesting properties and characterizations of them are investigated. also, some applications to fuzzy compact spaces are established.

Recently, numerous studies have demonstrated the effectiveness of a segmented inversion recovery fast gradient echo (seg IR-FGE) sequence for differentiating injured from normal myocardium. This technique for delayed enhancement imaging has been shown to be effective in identifying the presence and extent of myocardial infarction, as well as predicting improvement in contractile function after ...

in the present paper we introduce and study the notion of pairwise weakly lindelof bitopological spaces and obtain some results. further, we also study the pairwise weakly lindelof subspaces and subsets, and investigate some of their properties. it was proved that a pairwise weakly lindelof property is not a hereditary property.

With the development of heterogeneous network structure, dynamic user requests as well complex service types and applications scenarios, current networks may not accommodate increasingly stringent requirements. As a result, research beyond fifth generation (B5G) or sixth (6G) has been put on agenda. In B5G/6G networks, achieving automatic, flexible, cost-effective orchestration management resou...

OBJECTIVE To test the hypothesis that eustachian tube opening efficiency, measured as the fractional gradient equilibrated (FGE), is lower in 6-year-old children with no middle ear disease but a well-documented history of recurrent acute otitis media, as compared with children with a negative disease history (control). STUDY DESIGN Cross-sectional study. SETTING Tertiary care pediatric hosp...

Özet. Bu çalışmanın amacı, ardışıl devrelerin (sequential circuits) ölçeklenebilir düzenli ifadeler (regular expression) ile modellenmesi ve bu ölçeklenebilir model aracılığı ile sınanmasıdır (testing). Sınama işlemi için model tabanlı sınama dizileri (test sequence) kullanılacaktır. Devrenin modellenmesi için hedeflenen hatalar aracılığı ile durum uzayı (state space) sınırlandırılmaktadır. Böy...