El Fósforo es regulado por el riñón y sistema óseo orquestado principalmente la acción de parathormona (PTH) una molécula recientemente descrita como factor crecimiento fibroblástico 23 (FGF-23). Presentamos los casos dos pacientes madre-hijo con raquitismo hipofosfatémico ligado al cromosoma X. forma parte un grupo tubulopatías caracterizadas hiperfosfaturia. Se realizó estudio genético identi...

conclusions a fusion tag from the pet32 expression plasmid permits the recovery of the recombinant fusion fgf-2 from e. coli, without affecting its biological activity. objectives the objective of this study was to overexpress and purify the high-level active human bfgf in escherichia coli (e. coli). materials and methods this experimental study was conducted in the islamic republic of iran. af...

meningitis is an inflammation of the membranes that surround the brain and spinal cord, thereby involving the arachnoid, the pia and the cerebrospinal fluid (csf). it is divided into viral and bacterial meningitis. for different reasons the diagnosis of bacterial meningitis is very important. the examination of csf samples may provide information about causative microorganism. the sensivity of ...

Stromal cell-derived FGF-7 binds and activates only the resident FGFR2IIIb in epithelial cells while FGF-1 and FGF-2 exhibit a broader interaction with multiple isoforms of FGFR. Here we report the structure of FGF-7 that has been solved to 3.1 A resolution by molecular replacement with the structure of a dual function chimera of FGF-7 and FGF-1 (FGF-7/1) which was resolved to 2.3 A. Comparison...

background: angiogenesis gene therapy has long been sought as a novel alternative treatment for restoring the blood flow and improving the contractile function of the ischemic heart in selected clinical settings. angiogenic fibroblast growth factor-1 (fgf-1) is a promising candidate for developing a promising gene therapy protocol due to its multipotent ability to stimulate endothelial cell (ec...

Fibroblast growth factors (FGFs) are small polypeptides that mediate embryonic induction in vertebrates. FGFs are important mediators of mesoderm induction in Xenopus and chick and of limb development in mouse and chick (Rappolee and Werb, 1994; Niswander and Martin, 1992, 1993a,b; Vogel and Tickle, 1993). There are nine members of the FGF family (Hebert et al., 1990; Basilico and Moscatelli, 1...

Aims: The aim of this study was to find out the association between Fibroblast Growth Factor-23 (FGF-23), Insulin-Like Factor-1 (IGF-1), androgens, insulin resistance (IR), and bone mineral density (BMD) in patients with PCOS (Polycyctic Ovary Syndrome) healthy controls is presented.
 Materials Methods: FGF-23, IGF-1, Homeostatic Model Assessment for Insulin Resistance were evaluated 47 26...

Our objective was to develop a bone substitute coated with fibroblast growth factor-2 (FGF-2) that subsequently releases FGF-2. We investigated the use of our system of bone substitutes to induce bone formation. Hydroxyapatite ceramic buttons (HAP-CBs) were coated with FGF-2 by precipitation in supersaturated calcium phosphate solution. HAP-CBs were coated with high or low doses of FGF-2, denot...

1. Abstract 2. Introduction 3. FGF receptor structure 3.1. FGF receptor primary and schematic structures 3.2. Crystal structure of FGFR-1 3.3. Receptor splice variants 3.4. Expression patterns of FGF receptors 4. Heparan sulfate proteoglycans in FGF signaling 5. Activation of FGF receptors and initiation of signal transduction 5.1. Mode of activation and phosphorylation of FGF receptors 5.2. SH...

Backgrounds: Chronic kidney disease (CKD) is an abnormality in the that lasts for more than 3 months. Increased phosphate levels blood due to CKD will stimulate secretion of Fibroblast Growth Factor 23 (FGF-23). FGF-23 happens maintain balance because capacity excretion phosphorus kidneys decreases and leads incidence secondary hyperparathyroidism Parathyroid Hormone (PTH). This study aims eval...