Common bean (Phaseolus vulgaris L.) is a major food crop in Africa and its production plagued by diseases that reduce the potential yield, thus threatening security. This study evaluated compounds from Hagenia abyssinica for bioactivity against bacterial pathogens Xanthomonus axonopodis pv. phaseoli Pseudomonus savastanoi phaseolicola. One triterpenoid, 1,3,19-trihydroxy-2-oxo-12-ursen-28-oic a...

Bio-flavonoids comprise a group of phenolic secondary plant metabolites that are widespread in nature. Major flavonoids that have well categorized structures and well defined structure function-relationships are: flavans, flavanones, flavones, flavonols, flavanols, flavanonols, cetechins, anthocyanidins and isoflavones. Bio-flavonoids are well-known for their multi-directional biological activi...

Flavan-3-ols are involved in multiple metabolic pathways that induce inhibition of cell proliferation. We studied the structure-activity relationship of gallic acid (GA) and four flavan-3-ols: epigallocatechin gallate (EGCG), epigallocatechin (EGC), catechin (C), and epicatechin (EC). We measured the cell viability by the MTT assay and we determined the concentration of testing compound require...

western regions of the People’s Republic of China. As a Chinese folk medicine, this species has usually been used for treatment of rheumatic diseases and snake-bite. In previous investigations, we have reported the isolation and structural elucidation of several steroidal sapogenins, flavans, and a pregnane genin from this species. Our current phytochemical study for new efficient agents has le...

Within the past several years, the relation between diet and health has been accepted by the mainstream nutrition community and in this connection interest in the physiological role of bioactive compounds present in plants has dramatically increased over the last decade. The phytoestrogens are bioactive molecules present as nutritional constituents of widely consumed vegetables. Their name deri...

The effect of increasing concentration of ethanol (0, 4, 7.5 and 13 %) and contact time (respectively 1, 4, 7 and 10 days) on the extraction of phenolics from berry skins and seeds of the grape, Vitis vinifera 'Aglianico' and 'Uva di Troia', were examined. Two assays of post-fermentative maceration in two hydroalcoholic solutions at 11 and 13 % ethanol, were also performed. Chromatic properties...

Dementia and cognitive impairment have become the major concerns worldwide due to a significantly aging population, increasing life span and lack of effective pharmacotherapy. In light of limited pharmaceutical drug choices and the socioeconomic implications of these conditions, the search for safe and effective alternatives from natural sources has gained many attractions within the medical fo...

OBJECTIVE Alchornea floribunda leaves are widely used in ethnomedicine for the management of immuno-inflammatory disorders. We investigated the in vivo and in vitro antioxidant activity of the leaf extract, fractions and isolated compounds of A. floribunda. MATERIALS AND METHODS The ethyl acetate fraction of the methanol leaf extract was subjected to several chromatographic separations to iso...