Gastric residence time of oral controlled release system such as microspheres is increase by different techniques such as floating and mucoadhesive system. The objective of present investigation was to formulate floating microspheres of Nateglinide in order to increase gastric residence time, increased bioavailability and to reduce dose frequency of drug molecule. Novel o/w emulsion solvent dif...

The present study involves design and characterization of floating microspheres with Nateglinide as model drug for prolongation of gastric residence time. Nateglinide Floating Microspheres were prepared by w/o/o emulsification solvent diffusion technique using rate controlling polymers ethyl cellulose and hydroxy propyl methyl cellulose. The shape and surface morphology of prepared microspheres...

Purpose: To formulate and evaluate floating microparticulate oral diltiazem delivery system for possible delivery to the heart. Method: Floating microspheres were prepared using cellulose acetate and Eudragit RS100 polymers by emulsion solvent evaporation technique. The dried floating microspheres were evaluated for micromeritic properties (flow properties, density, particle size determination)...

Gastroretentive drug delivery system i.e. floating microspheres of an H2 receptor antagonist drug ‘famotidine’ was successfully prepared using combination of polymer as hydroxyl propyl ethyl cellulose K15M (HPMC K15M) and cellulose acetate via non-aqueous solvent evaporation (oil-in-water) technique. Famotidine loaded floating microsphere formulations were prepared by dissolving polymer in solv...

Floating microspheres have emerged as a potential candidate for gastroretentive drug delivery system. For developing a desired intragastric floatation system employing these microspheres, it is necessary to select an appropriate balance between buoyancy and drug releasing rate. These properties mainly depend on the polymers used in the formulation of the microspheres. Hence it is necessory to s...

Most of the floating systems have an inherent drawback of high variability in the GI transit time, invariably affecting the bioavailability of drug. An attempt has been made to develop floating drug delivery system for improving the drug bioavailability by prolongation of gastric residence time of famotidine in stomach. The floating microballoons were prepared using polymer Eudragit L-100 by so...

ABSTRACT The present study involves preparation and evaluation of floating microspheres with famotidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers acrycoat S100 and chitosan. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy, respe...