Microfluidic flow-focusing devices offer excellent control over fluid flow, enabling formation of drops with a narrow size distribution. However, the throughput of microfluidic flow-focusing devices is limited and scale-up through operation of multiple drop makers in parallel often compromises the robustness of their operation. We demonstrate that parallelization is facilitated if the outer pha...

Picoliter drops made in microfluidic devices can serve as individual compartments for chemical reactions and can be processed at kilohertz rates with high precision. This combination of speed and containment is very useful for highthroughput screening, for discovering novel drugs, for sorting analytes and worms, and for directed evolution of enzymes and cells. For applications in microfluidics,...

We study numerically and experimentally the stability of transonic flow focusing used in serial femtosecond crystallography (SFX) to place complex biochemical species into beam focus. Both numerical experimental results indicate that minimum rate for steady jetting increases slightly with gas stagnation pressure. There is a remarkable agreement between limit predicted by global analysis obtaine...

In this work, a series of experiments and numerical simulations performed using volume-of-fluid approach were carried out to investigate the flow miscible viscous fluid systems through microfluidic focusing devices with one central inlet stream (with “fluid 1”) two lateral streams 2”). The combined effect viscosity ratio velocity on characteristics focused outlet was assessed in channels differ...