We present an experimental method, which provides information on the steric and electronic properties of ligands in metal complexes. This approach is based equilibrium ion-pairing a cationic [(NHC)Ir(cod)]+ fluorescent bodipy-sulfonate (bdpSO3?). The close ion-pair [(NHC)Ir(bdpSO3)(cod)] toluene solution weakly fluorescent, but dissociates into solvent-separated ion pairs upon exposure to sligh...

A new series of perylene and hemicoronene diimides, obtained by visible light photocyclization, are presented, between them some remarkable examples that soluble in only water, give nanoparticles self-association. Those compounds work as fluorescent materials water complexation with cucurbit[7]uril, well selective G-quadruplex binding ligands cytotoxic activity when the interaction G4 was suffi...

Advances in fluorescence-based imaging technologies have helped propel the study of real-time biological readouts and analysis across many different areas. In particular the use of fluorescent ligands as chemical tools to study proteins such as G protein-coupled receptors (GPCRs) has received ongoing interest. Methods to improve the efficient chemical synthesis of fluorescent ligands remain of ...

The biologically relevant arenes ethyl salicylate and salicylic amide as well the fluorescent coumarin pyrene units were functionalized with a cyclopentadiene unit. Re 99mTc complexes of latter two synthesized fully characterized. During crystallization ligands, [2+2] [6+6] cycloadditions observed for modified coumarin. A light-induced mechanism, supported by DFT calculations, is proposed these...

The activation of peroxisome-proliferator-activated receptor-γ (PPARγ), which plays a central role in adipocyte differentiation, depends on ligand-dependent co-activator recruitment. In this study, we developed a novel method of PPARγ ligand screening by measuring the increase in fluorescent polarization accompanied by the interaction of a fluorescent co-activator and PPARγ. Sterol receptor co-...