BACKGROUND AND PURPOSE Fluoxetine, a selective serotonin reuptake inhibitor, elevates brain concentrations of the neuroactive progesterone metabolite allopregnanolone, an effect suggested to underlie its use in the treatment of premenstrual dysphoria. One report showed fluoxetine to activate the aldo-keto reductase (AKR) component of 3α-hydroxysteroid dehydrogenase (3α-HSD), which catalyses pro...

Although cocaine-induced conditioned taste aversions (CTA) are well documented, little is known about the basis for cocaine's aversive effects. To address the role of serotonin (5-HT) in cocaine-induced aversions, the present experiments used the cross-drug preexposure design in which the effects of exposure to fluoxetine, a selective 5-HT reuptake inhibitor (SSRI) with 5-HT transporter (SERT) ...

OBJECTIVE Dysfunction of neural plasticity in the brain is known to alter neural networks, resulting in depression. To understand how fluoxetine regulates molecules involved in neural plasticity, the expression levels of NCAM, NCAM140, CREB and pCREB, in rat C6 glioma cells after fluoxetine treatment were examined. METHODS C6 cells were cultured after 20 min or after 6, 24 or 72 h treatments ...

BACKGROUND Fluoxetine and placebo were studied in a population of combat veterans with severe, chronic PTSD. METHODS Twelve male veterans with PTSD were enrolled in a 12 week double-blind evaluation of fluoxetine and placebo. Mean fluoxetine dose at endpoint (week 12) was 48 mg/day with a range of 10 mg to 60 mg. RESULTS One fluoxetine patient responded (17%) and two of the six placebo pati...

The aim of this double-blind study was to compare the efficacy and safety of venlafaxine vs. fluoxetine in the treatment of patients with depression and anxiety. A total of 146 moderately depressed patients with associated anxiety were randomized to receive 75 mg/d venlafaxine or 20 mg/d fluoxetine for 12 wk. Dose increases were permitted after 2 wk of treatment, to 150 mg/d venlafaxine and 40 ...

A procedure has been developed for measuring fluoxetine and its desmethyl metabolite, norfluoxetine, in serum by reversed-phase high-performance liquid chromatography (HPLC), with ultraviolet detection at 226 nm. Fluoxetine and norfluoxetine are isolated from serum by liquid-liquid extraction. They are then separated by HPLC and quantified, with reduced haloperidol as the internal standard. Flu...

objective: to investigate the effect of fluoxetine as an ssri on menstrual disorders. materials and methods: in this cross-sectional study 200 women referring to the islamic azad university affiliated hospitals during march 2011- march 2010 were divided into 4 groups. all included patients in this study had the chief complaint of mood disorders in peri- menstrual period. all patients received d...

Nineteen mentally retarded inpatients with epilepsy and a history of current or recent aggressive behavior were treated with 20 mg of fluoxetine daily. All were concurrently taking other psychotropic medications, including carbamazepine and neuroleptics. A standardized rating scale (MOAS) was used to assess the effects of fluoxetine on aggressive behavior. There were wide individual differences...

OBJECTIVE To report a syncopal episode associated with fluoxetine in a young, relatively healthy man. DESIGN Single case report. SETTING 585-bed private hospital. PATIENT A 30-year-old man with hypertension, esophageal ulcers, and syncope of recent onset. RESULTS Fluoxetine was started six weeks prior to the syncopal episode in this patient, and is the medication most temporally associa...

BACKGROUND Little is known about the effect of pharmacotherapy in the prevention of post-traumatic stress disorder (PTSD) relapse. AIMS To assess the efficacy and tolerability of fluoxetine in preventing PTSD relapse. METHOD This was a double-blind, randomised, placebo-controlled study. Following 12 weeks of acute treatment, patients who responded were rerandomised and continued in a 24-wee...