Purpose: To determine the regulation of the expression of osteoprotegerin and receptor activator of nuclear factor-kappa B ligand in human dental follicle cells by colony-stimulating factor-1, parathyroid hormone-related protein and bone morphogenetic protein-2. Materials and Methods: Primary human dental follicle cells were cultured. The fifth passaged human dental follicle cells were separate...

Age-specific incidence of epithelial ovarian cancer indicates a hormonal etiology and relates it to menopause, a time during the aging process when ovaries fail but the pituitary becomes overactive to produce a greater amount of gonadotropins. There is a 10-fold to 20-fold increase in the follicle-stimulating hormone (FSH) level and a 3-fold to 5-fold increase in the luteinizing hormone (LH) le...