A neuronal microneedle, a single-crystalline silicon microneedle with fluidic microchannels and microelectrodes, is developed for localized stimulation of and recording from neural cells. The neuronal microneedle delivers drugs such as excitatory amino acids at the cellular level as well as electrically records neural signals from neural cells. The fluidic behavior, the mechanical stability, an...

BACKGROUND Microneedle is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. No previous study showed a therapeutic effect of microneedle itself on hair growth by wounding. OBJECTIVE The aim of this study is to investigate the effect of repeated microwound formed by microneedle on hair growth and hair growth-related genes in a murine model. MET...

BACKGROUND Microneedle-mediated drug delivery is a promising method for transdermal delivery of insulin, incretin mimetics, and other protein-based pharmacologic agents for treatment of diabetes mellitus. One factor that has limited clinical application of conventional microneedle technology is the poor fracture behavior of microneedles that are created using conventional materials and methods....

This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless steel microneedles reliably pierce the outer layers...

Microneedle Arrays In article number 2100128, Jamil Azzi, Natalie Artzi, and co-workers present a theranostic microneedle-based platform for the simultaneous delivery of immune modulators sampling skin interstitial fluid to monitor response therapy. Using model allogeneic transplant in mice, they show that microneedle-mediated therapy can help regulate system locally, without inducing systemic ...

OBJECTIVES The purpose of this study was to assess the efficacy and safety of a novel, multielectrode, duty-cycled radiofrequency ablation (RFA) system for long-standing persistent atrial fibrillation (AF). BACKGROUND RFA for persistent AF remains a lengthy and challenging procedure. METHODS In 5 European centers, 50 patients with long-standing persistent AF underwent RFA. A circular pulmon...

MEMS (Micro Electro Mechanical System) design systems are used for the development of microneedles, which are used for drug delivery. The drug delivery through micronnedle is painless which is not in case of transdermal needles. In this paper the simulation and analysis of microneedle is presented. The typical structure of a microneedle is simulated for studies of the structural behavior of mic...