V. Conditions Associated with Genetic IGF-I Resistance in Humans A. African Efe Pygmies B. Leprechaunism and other genetic disorders associated with severe insulin resistance C. Deletions of the distal arm of chromosome 15 D. Rare examples of “idiopathic” short stature associated with elevated circulating levels of IGF-I VI. Conditions Associated with Acquired IGF-I Resistance in Humans A. HIV-...

Background Mauriac’s syndrome (MS) may occur in children with poor controlled type 1 diabetes mellitus (DM1) and is associated with growth impairment, puberty delay and hepatomegaly with elevated transaminases. It is a rare syndrome firstly described by Mauriac in 1930 and has become even less common after the emergence of advances on diabetes treatment, but still exists. The exact incidence is...

Question 1 First, we have that λ − λ − 2 = (λ + 1)(λ − 2). Therefore, it is true that the eigenvalues of the corresponding adjacency matrix come in pairs of additive inverse. However, notice that ± √ −1 are eigenvalues, and therefore the associated matrix cannot be symmetric (there would only be real eigenvalues). We conclude that no undirected graph can have the above characteristic polynomial...

These lecture notes discuss some aspects of the Planck1 mission, whose prime objective was a very accurate measurement of the temperature anisotropies of the Cosmic Microwave Background (CMB). We announced our findings a few months ago, on March 21st , 2013. I describe some of the relevant steps we took to obtain these results, sketching the measurement process, how we processed the data to obt...

Francois Recanati presents the basic features of the *indexical model* of mental files, and defends it against several interrelated objections. According to this model, mental files refer to objects in a way that is analogous to that of indexicals in language: a file refers to an object in virtue of a contextual relation between them. For instance, perception and attention provide the basis for...

Hepatic glycogenosis in type 1 diabetes mellitus (DM) can be caused by poor glycemic control due to insulin deficiency, excessive insulin treatment for diabetic ketoacidosis, or excessive glucose administration to control hypoglycemia. Mauriac syndrome, which is characterized by hepatomegaly due to hepatic glycogenosis, growth retardation, delayed puberty, and Cushingoid features, is a rare dia...