The aim of this study is to compare three different dissolution methods assess the drug release from oral lyophilisates, based on interpolyelectrolyte complexes (IPECs). IPECs were prepared by mixing solutions a linear polymer, Eudragit® EPO, with polymer cross-linked structure, Noveon® AA-1 or Carbopol® 10 Ultrez (in ratios 1:2 and 1:1, respectively). Metformin metronidazole used as model drug...

Present study was undertaken to assess the potential of Glycerosomes as a novel drug delivery system for topical application of Minoxidil. Pre-formulation studies were done for identification of drug as well as for determination of its physiochemical properties. Spectra of various mixtures of drug and excipients do not show any additional peak thus, indicating compatibility with each other. Gly...

In skin penetration studies, HPLC-MS/MS analysis on extracts of heat-separated epidermis and dermis provides an estimate the amount drug penetrated. this study, MALDI-MSI enabled qualitative distribution endogenous molecules molecule, tofacitinib quantitative in epidermis. The delivery to was investigated a Franz diffusion cell using three different formulations (two oil-in-water creams, C1 C2 ...

In vitro release test (IVRT) was developed for evaluation of release profile of Capsaicin from Capsaicin topical gel formulations. The method was developed using a Vertical Franz diffusion cell, commercially available synthetic membranes, Hydro alcoholic receptor medium and quantification by HPLC with UV detection. Good release profile of Capsaicin was observed with 0.2μm Teflon membrane, Ethan...

Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents ...

Understanding the interactions of nanoparticles (NPs) with skin is important from a consumer and occupational health and safety perspective, as well as for the design of effective NP-based transdermal therapeutics. Despite intense efforts to elucidate the conditions that permit NP penetration, there remains a lack of translatable results from animal models to human skin. The objectives of this ...

One of the known drawbacks of in vitro dermal absorption methods is their high interlaboratory variation. Although often attributed to biological skin differences, it has been shown that validation of other parameters such as temperature and stirring speed can reduce the high variability observed. The Organisation for Economic Co-operation and Development (OECD) and, at the EU level, the Scient...

OBJECTIVE We aimed to compare the possible controlled release profile of multilamellar liposomal bupivacaine formulations with non-liposomal forms in artificial cerebrospinal fluid (CSF) under in vitro conditions. METHODS Liposome formulations were prepared using a dry-film hydration method. Then, an artificial CSF-buffered solution was prepared. Bupivacaine base with liposomal bupivacaine ba...

gel dosage forms are successfully used as drug delivery systems considering their ability to control drug release and to protect medicaments from a hostile environment. the aim of this work was to investigate the properties of carbopol 934p polymeric system in water-misible cosolvents such as glycerin and alcohol. benzocaine is a local anesthetic and the mucosal gel formulation is applied in th...

here we report a novel approach for preparation of a 6-day transdermal drug delivery system (tdds) as treatment for mild to moderate alzheimer’s disease. the spray drying method was used to prepare microparticles containing the anti-alzheimer drug. the content of the drug was determined by high performance liquid chromatography (hplc) method. the morphology and size range of the microparticles ...