peritoneal dialysis is an established form of renal replacement therapy used in many patients with end-stage renal disease. the key to a successful chronic peritoneal dialysis is a permanent and safe access to the peritoneal cavity. this study was conducted in order to evaluate the catheter survival and its related factors in imam khomeini hospital. a total of 80 catheters were inserted into 69...

HER2 and CDK4/6 are undoubted two most important biological targets for breast cancer. Anti-HER2 treatments enhance objective response and progression-free survival/disease-free survival as well as overall survival. Three CDK4/6 inhibitors consistently improve objective response and progression-free survival; however, overall survival data are waited. Optimization of chemotherapy and endocrine ...

background: osteosarcoma is the most common bone sarcoma, and the third most common malignancy in children and adolescents. before 1970, amputation was the sole treatment. eighty percent of patients died from metastatic diseases, most commonly in the lungs. over the past three decades, effective neoadjuvant (preoperative) and adjuvant (postoperative) chemotherapy protocols have improved the abi...

background uterine cancer stays the most prevalent gynecologic malignancy in developed countries. providing suitable solutions to treat this disease is required to the early diagnosis of this cancer. objectives the aim of this study was to evaluate the effectiveness of multiple-site lymph node sampling in patients with the endometrioid type of endometrial cancer. patients and methods demographi...

Cardiovascular risk prediction functions offer an important diagnostic tool for clinicians and patients themselves. They are usually constructed with the use of parametric or semi-parametric survival regression models. It is essential to be able to evaluate the performance of these models, preferably with summaries that offer natural and intuitive interpretations. The concept of discrimination,...

Dear Editor, We read with some disquiet the article published by your journal entitled “Epidemiology, Management and Treatment Outcome of Medulloblastoma in Singapore” by Chan et al.1 It succinctly reviewed the 39 paediatric patients with medulloblastoma seen over a 9-year period in Singapore, and made 2 statements: 1. The clinical outcomes seen “were inferior to reported outcomes in establishe...