AIMS Fos-related antigen 1 (Fra-1) is a member of the activator protein 1 (AP-1) transcription factor family. Our objective was to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis. METHODS AND RESULTS Fra-1 expression was investigated by immunohistochemistry in two tissue microarrays containing, respectively, 85 ductal carcinoma in situ (DCIS) and 771 invasi...

many of nonlinear systems in the field of engineering such as nano-resonator and atomic force microscope can be modeled based on duffing equation. analytical frequency response of this system helps us analyze different interesting nonlinear behaviors appearing in its response due to its rich dynamics. in this paper, the general form of duffing equation with cubic nonlinearity as well as paramet...

This paper deals with diagnostic methods of the internal faults in power transformers. The diagnostic process uses some of the current diagnosis methods (e.g. oil test, dissolved gases analysis (DGA), partial discharge (PD), etc.) to determine the condition of the transformer. In this process, the most frequent diagnostic methods were listed and applied practically to be compared. A conventiona...

Inappropriate lung inflammatory response following oxidant and toxicant exposure can lead to abnormal repair and disease pathogenesis, including fibrosis. Thus early detection of molecular and cellular processes and mediators promoting lung inflammation is necessary to develop better strategies for therapeutic intervention and disease management. Previously, we have shown that transcription fac...

Members of eight Saskatchewan families with fragile (X) X-linked mental retardation were studied in an attempt to relate frequency to age and intelligence. The mean IQ of 37 affected men was 35 (range 10-66). The mean IQ of 32 carriers was 88 (range 57-119), and the mean IQ of 13 females who remain at risk for being carriers, have no affected sons, and who failed to demonstrate the fra(X) was 1...

Malignant mesothelioma is a cancer with poor prognosis associated with exposures to asbestos. The mechanisms of asbestos-induced mesotheliomas are unclear, and studies are required to find diagnostic tools and therapies to improve the survival rates of patients. After oligonucleotide microarray analysis (Affymetrix array) of normal rat pleural mesothelial (RPM) cells, RPM cells exposed to croci...

The chondrocytes of the articular condylar cartilage proliferate, hypertrophy and ultimately undergo apoptosis (programmed cell death), being replaced by osteoblasts. Converging results consolidate activator protein-1 (AP-1) transcription factor as the pivotal downstream effector in the early response of stress-sensitive cells to mechanical loading, and the Fra-1, Fra-2, JunB and JunD members o...

In this paper, a new method for estimation of transient parameters of transformer high voltage winding using the artificial neural networks (ANN) is proposed. An ANN with different structures is trained for parameters estimation of transformer winding Detailed Model that data is generated by analysis of frequency response. It is shown that feed-forward back propagation network with Levenberg-Ma...

This paper presents a new investigation to detect various faults within the three-phase star and delta induction motors (IMs) using frequency response analysis (FRA). In this regard, experimental measurements FRA are performed on three IMs of ratings 1 HP, 3 HP 5.5 in normal conditions, short-circuit fault (SC) open-circuit (OC) conditions. The SC OC applied artificially between turns (Turn-to-...