Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression post-transcriptionally. The lethal-7 (let-7) miRNA family was suggested to be involved in the inflammation process and IL-6 was shown to be one of its targets. In the present study, we report elevation...

INTRODUCTION Pooling of multicenter brain imaging data is a trend in studies on ageing related brain diseases. This poses challenges to MR-based brain segmentation. The performance across different field strengths of three widely used automated methods for brain volume measurements was assessed in the present study. METHODS Ten subjects (mean age: 64 years) were scanned on 1.5T and 3T MRI on ...

We describe a simple, but powerful, program logic for reasoning about C11 relaxed accesses used in conjunction with release and acquire memory fences. Our logic, called fenced separation logic (FSL), extends relaxed separation logic with special modalities for describing state that has to be protected by memory fences. Like its precursor, FSL allows ownership transfer over synchronizations and ...

While traditional network security policies have been enforced by manual configuration of individual network components such as router ACLs, firewalls, NATs and VLANs, emerging enterprise network designs and products support global policies declared over high level abstractions [2, 1, 14, 13]. We further the evolution of simpler and more powerful network security mechanisms by designing, implem...

Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifically, isolating preadolescent female mice from littermates for <24 hr increased first spike latenc...

Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal paper, and there has been a steady stream of publications (130+) over the years. The present review will focus on several issues not previously covered in earlier reviews, su...

The FGFR1-5-HT1A heteroreceptor complexes are involved in neuroplasticity in the rat hippocampus and in the mesencephalic raphe 5-HT nerve cells. There exists a 5-HT1A protomer enhancement of FGFR1 protomer signaling. Acute and 10 day treatment with intracerebroventricular (i.c.v.) FGF-2 and the 5-HT1A agonist 8-OH-DPAT produced enhanced antidepressant effects in the forced swim test (FST). We ...

Probabilistic properties of spiking time-series obtained in vivo from singular neurons belonging to Red Nucleus of brain are analyzed for two groups of rats: genetically defined rat model of depression (Flinders Sensitive Rat Line – FSL) and a control (healthy) group. The FSL group shows a distribution of interspike intervals with a much longer tail than that found for normal rats. The former d...

MNI coordinates determined using SPM2 and FSL/FLIRT with the ICBM-152 template were compared to Talairach coordinates determined using a landmark-based Talairach registration method (TAL). Analysis revealed a clear-cut bias in reference frames (origin, orientation) and scaling (brain size). Accordingly, ICBM-152 fitted brains were consistently larger, oriented more nose down, and translated sli...

In the present work, we propose a novel method utilizing only decoder for generation of pseudo-examples, which has shown great success in image classification tasks. The proposed is particularly constructive when data are limited quantity used semi-supervised learning (SSL) or few-shot (FSL). While most previous works have an autoencoder to improve performance SSL, using single may generate con...