نتایج جستجو برای: functional pituitary adenomas

تعداد نتایج: 631995  

Journal: :Veterinary Journal 2021

Pituitary tumours are common in dogs and being increasingly recognized cats. usually classified as adenomas should only be carcinomas when there is evidence of metastatic spread the tumour, which rare. Despite benign nature most pituitary tumours, they can still compress or invade neighbouring tissues. functional (hormonally active) non-functional silent). The aim this review was to provide an ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
David Calligaris Daniel R Feldman Isaiah Norton Olutayo Olubiyi Armen N Changelian Revaz Machaidze Matthew L Vestal Edward R Laws Ian F Dunn Sandro Santagata Nathalie Y R Agar

We present a proof of concept study designed to support the clinical development of mass spectrometry imaging (MSI) for the detection of pituitary tumors during surgery. We analyzed by matrix-assisted laser desorption/ionization (MALDI) MSI six nonpathological (NP) human pituitary glands and 45 hormone secreting and nonsecreting (NS) human pituitary adenomas. We show that the distribution of pi...

2016
Weiyan Xie Chunhui Liu Dan Wu Zhenye Li Chuzhong Li Yazhuo Zhang

Pituitary adenomas constitute 15-20% of intracranial neoplasms. Previously we reported that cyclin-dependent kinase 5 (CDK5) is upregulated in pituitary tumors associated with activating protein p35, and plays an essential role in pituitary adenomas progression. Here we explored the mechanisms of CDK5 signaling in prolactin pituitary adenomas. Our data indicate that p35 expression and CDK5 acti...

Journal: :Genetics and molecular research : GMR 2015
J H Mao H Guo N Si L Qiu L F Guo Z S Sun Y Xiang X H Yang W G Zhao W C Zhang

Pituitary adenomas can cause endocrine disorder and organ damage, with some aggressive ones leading to a high postoperative recurrence rate. The occurrence and development of these type of tumors is closely related with matrix metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs (TIMPs). In this study, the relationship between pituitary adenoma invasion and the changes in ...

Journal: :International journal of clinical and experimental pathology 2013
Margarita González del Pliego Elsa Aguirre-Benítez Karina Paisano-Cerón Irene Valdovinos-Ramírez Carlos Rangel-Morales Verónica Rodríguez-Mata Carmen Solano-Agama Dolores Martín-Tapia María Teresa de la Vega Miguel Saldoval-Balanzario Javier Camacho María Eugenia Mendoza-Garrido

Pituitary adenomas can invade surrounded tissue, but the mechanism remains elusive. Ether à go-go-1 (Eag1) potassium channel and epidermal growth factor receptors (ErbB1 and ErbB2) have been associated to invasive phenotypes or poor prognosis in cancer patients. However, cells arrange their cytoskeleton in order to acquire a successful migration pattern. We have studied ErbBs and Eag1 expressio...

Journal: :Anticancer research 2005
Tadej Strojnik Tamara T Lah Boris Zidanik

BACKGROUND New biological markers are needed for diagnosis of atypical pituitary adenoma. The study aimed to evaluate cathepsins B and L and inhibitor stefin A in relation to their aggressive progression. PATIENTS AND METHODS We evaluated 19 adenomas and 10 normal hypophyses. Adenomas were divided according to their histological features and according to their functional activity, e.g. hormon...

Journal: :Endocrinology and metabolism clinics of North America 2015
Paula Bruna Araujo Leonardo Vieira Neto Mônica R Gadelha

The improved management of pituitary adenomas has led to an increasing number of pregnancies in patients harboring pituitary adenomas. Therefore, adequate management of pregnant women with pituitary adenomas is of growing importance. Because pregnancy produces several physiologic changes to the endocrine system, especially to the pituitary gland, endocrinologists must be knowledgeable and skill...

Journal: :The Journal of clinical investigation 2003
Shlomo Melmed

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid, adrenal, reproductive, and growth functions. The gland responds to complex central and peripheral signals by trophic hormone secretion and by undergoing reversible plastic changes in cell growth leading to hyperplasia, involution, or benign adenomas arising from functional pituitary cells. Discussed ...

2006
M. JOSEFA JOSE M. DE CAMPOS ALBERTO ISLA CACILDA CASARTELLI JUAN A. REY

The epigenetic changes in pituitary adenomas were identified by evaluating the methylation status of nine genes (RB1, p14ARF, p16INK4a, p73, TIMP-3, MGMT, DAPK, THBS1 and caspase-8) in a series of 35 tumours using methylationspecific PCR analysis plus sequencing. The series included non-functional adenomas (n=23), prolactinomas (n=6), prolactinoma plus thyroid-stimulating hormone adenoma (n=1),...

Journal: :Turk patoloji dergisi 2015
Karen Gomez-Hernandez Shereen Ezzat Sylvia L Asa Özgür Mete

Pituitary adenomas comprise a heterogenous group of adenohypophyseal tumours with distinct clinicopathological features across both the clinically functioning and silent groups. Although, predicting a clinically aggressive course remains challenging, accurate subtyping of pituitary adenomas offers valuable prognostic information that together with other clinical and radiological information ser...

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