Multiplexed SERS imaging of receptor proteins on the surface of mammalian cells has been carried out using functionalized silver nanoparticles. Deconvolution of four differently functionalized nanoparticles is readily achieved, and using this approach, receptor co-localization can be probed and protein-protein interactions can be elucidated at the surface of cells.

Nanotechnology can be an important tool to improve the permeability of some drugs for the blood-brain barrier. In this work we created a new system to enter the brain by functionalizing solid lipid nanoparticles with apolipoprotein E, aiming to enhance their binding to low-density lipoprotein receptors on the blood-brain barrier endothelial cells. Solid lipid nanoparticles were successfully fun...

We report in this paper novel chemistry that addresses the problem of surfactant solubility in supercritical CO2 for metal nanoparticle synthesis. This new approach for the preparation of organic-functionalized inorganic nanoparticles relies on the reduction of a metal precursor in a CO2-containing insoluble polymer. Reduction of the metal with H2 leads to small nanocrystals stabilized by the p...

Normal micelle microemulsion method was utilized for fabrication of organically modified silica (ORMOSIL) nanoparticles. The void and dye-doped nanoparticles were synthesized in nonpolar core of two different surfactants including Aerosol OT and Tween 80. The nanoparticles were characterized using transmission electron microscopy, dynamic light scattering, and zeta potential analysis. Our resul...

Nanomaterials are the leading edge to the rapidly developing nanotechnology. For the synthesis of nanomaterials over a wide range of chemical composition, the development of reliable and efficient methods is a challenging issue in nanotechnology. In context to this green synthesis of nanoparticles using biological systems, plant products and microorganisms are potentially considerable because o...

Love-wave gas sensors based on surface functionalized iron oxide nanoparticles has been developed in this research. Amino-terminated iron oxide nanoparticles were deposited, by a spin coating technique, onto the surface of Love-wave sensors, as a very reproducible gas-sensing layer. The gases tested were organic solvents, such as butanol, isopropanol, toluene and xylene, for a wide and low conc...

Chitosan functionalized Fe3O4-Au core shell nanoparticles have been prepared using a two-step wet chemical approach using NaBH4 as reducing agent for formation of Au in ethylene glycol. X-ray diffraction studies shows individual phases of Fe3O4 and Au in the as prepared samples with crystallite size of 5.9 and 11.4 nm respectively. The functionalization of the core-shell nanostructure with Chit...

Synthesis and characterization of two functionalized gold nanoparticles by using of two poly functional amino acids (L-Arginine and L-Aspartic acid) are reported. The gold nanoparticles were reduced by sodium citrate and functionalized with L-Arginine at the pH of 7 and 11 and L-Aspartic acid at the pH of 7. Transmission electron microscopy, UV-Vis spectroscopy, dynamic light scattering, zeta p...

Antibody or peptide conjugated nanoparticles are a new technology useful for targeting and imaging biological systems. However, characterization of these functionalized nanoparticles has not yet been accomplished. This is essential for the evaluation of the efficacy of the nanoparticles. In this study, we characterize antibody functionalized quantum dot nanocrystals from experimental data. We f...

Treating pathogens is becoming challenging because of multidrug resistance and availability of limited alternative therapies which has further confounded this problem. The situation becomes more alarming when multidrug resistant pathogens form a 3D structure known as biofilm. Biofilms are formed in most of the infections especially in chronic infections where it is difficult to eradicate them b...