Furazolidone and nitrofurantoin, oral nitrofuran derivatives with broad-spectrum antimicrobial properties already in clinical use, were compared for activity against Pneumocystis carinii in an immunosuppressed rat model of P. carinii pneumonia. Furazolidone exhibited only slight activity as a prophylactic agent but was moderately effective in the therapy of pneumocystosis. The median histologic...

We read with great interest the article published by Hosseini et al.1 in October issue of Middle East Journal of Digestive Diseases. Briefly, in this article, authors concluded that furazolidone based therapeutic regimens (in moderate and even high-dose) were not preferable for first-line treatment against H.pylori infection among the northern population in Iran.1 Altogether, some points we fou...

Coccidiosis is a protozoal and occasionally fatal diarrheic disease of goats imposing heavy economic losses to farming community. This study aimed to evaluate the efficacies of Furazolidone, Sulfadimidine and Amprolium against coccidiosis in Beetal goats. Twenty-four (24) Beetal goats naturally infected with coccidiosis were randomly divided into four groups of 6 (A-D). Goats in groups A, B and...

Furazolidone was given to male Nubian goats for 5 days at a therapeutic dose of 10 mg/kg or at a dose of 40 mg/kg, and the effect on semen morphology and biochemistry was studied. At the lower dose, furazolidone significantly reduced seminal ejaculate volume, the number of motile spermatozoa per ejaculate and the number of live spermatozoa per ejaculate, while secondary abnormalities increased....

BACKGROUND The effectiveness of classic standard triple therapy regimen of helicobacter pylori (H. pylori) eradication has decreased to unacceptably low levels, largely related to development of resistance to metronidazole and clarithromycin. Thus successful eradication of H. pylori infections remains challenging. Therefore alternative treatments with superior effectiveness and safety should be...

Efficacy of furazolidone and nalidixic acid was compared in a randomized trial involving 72 children with acute invasive diarrhea. Thirty six children received furazolidone (7.5 mg/kg/ day) and 36 children received nalidixic acid (55 mg/kg/day). Clinical characteristics of the two treatment groups were comparable on admission. Of these, 34 children in furazolidone treated group and 29 children ...

Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients...

metronidazole and furazolidone were compared for efficacy in 268 seven to 11 year old children infected with giardiasis. with metronidazole the cure rate was 82.3% and 80.0% in boys and girls respectively, while furazolidone showed an efficacy of74.4% and 71. 7% in the corresponding groups. the overall efficacy was 81.1 % with metronidazole and 73.3% with furazolidone. there were no significant...

background: furazolidone has been used as an alternative for clarithromycin or metronidazole in helicobacterpylori ( h . pylori ) eradication regimens.  in iran, 14-day furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. therefore, we designed a study to compare the efficacy of two 10-day triple regimens ...

Objective: To assess the efficacy and tolerability of using high dose Furazolidone just during the first week of two different quadruple regimens in eradicating H. pylori. Methodology: One-hundred sixty patients with duodenal ulcer and positive H. pylori infection were randomly allocated into two groups. Group A received (OAM-F) omeprazole (20 mg BID), amoxicillin (1gr BID), metronidazole (500m...