This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF...

periodontal regeneration is a main aspect in the treatment of teeth affected by periodontitis. periodontal regeneration in furcation areas is quite challenging, especially when it is in interproximal region. there are several techniques used alone or in combination considered to achieve periodontal regeneration, including the bone grafts or substitutes, guided tissue regeneration (gtr), root su...

BACKGROUND The objective of this multicenter, randomized trial was to compare enamel matrix derivative (EMD; test) with barrier membranes (control) for the treatment of mandibular buccal Class II furcation defects. METHODS Forty-five patients with 90 comparable defects on contralateral molars were included. Defects were randomly assigned to EMD or bioabsorbable barrier membrane; the contralat...

Furcation lesions are associated with increased risk of progressive loss of connective tissue attachment, alveolar bone resorption, and tooth mortality (Bjorn and Hjort, 1982; Becker et al, 1984; Wang et al, 1994; Wood et al, 1989; Hirshfield and Wasserman, 1978; McFall, 1982; Carranza and Jolkovsky, 1991), representing one of the greatest challenges in periodontal therapy. Surgical management ...

One of the most important indications for guided tissue regeneration (GTR) treatment is class II furcation lesion. However, periodontal regeneration of this type of defect, although possible, is not considered totally predictable, especially in terms of complete bone fill. Many factors may account for variability in the response to regenerative therapy in class II furcation. The purpose of this...

Introduction: Clinicians tend to encounter unfavorable situations in the treatment of teeth with severe attachment loss. Periodontal regeneration has been a successful therapeutic approach treatments that require long-term prognosis improvement. This case shows benefits combined regenerative periodontal therapy patient molar severely compromised by furcation, intrabony defects and loss apex. Ca...

statement of problem: among periodontal defects, the furcation involvement represents one of the most chalenging scenarios due to the difficulty of achieving a predictable improvement regardless of the type of periodontal therapy. moreover, the presence of furcation involvement has been demonstrated to considerably affect tooth prognosis. thus, treatment of furcation defects is a challenge in c...

statement of problem: there are limited histomorphometric studies on biologic efficacy of high density tetrafluoroethylen (d-ptfe) membrane. objectives: to investigate the healing of surgically induced grade ii furcation defects in dogs following the use of dense polytetrafluoroethylene as the barrier membrane and to compare the results with the contra lateral control teeth without the applicat...

BACKGROUND AND AIMS Plasma rich in growth factors (PRGF) is a concentrated suspension of growth factors, which is used to promote periodontal tissue regeneration. The aim of this randomized, controlled, clinical trial was to evaluate of the treatment of grade II mandibular molar furcation involvement using autogenous bone graft with and without PRGF. MATERIALS AND METHODS In this double-blind...