SUMMARY Gene fusions are being discovered at an increasing rate using massively parallel sequencing technologies. Prioritization of cancer fusion drivers for validation cannot be performed using traditional single-gene based methods because fusions involve portions of two partner genes. To address this problem, we propose a novel network analysis method called fusion centrality that is specific...

Chromosomal translocation, which generates fusion proteins in blood tumor or solid tumor, is considered as one of the major causes leading to cancer. Recent studies suggested that the disordered fragments in a fusion protein might contribute to its carcinogenicity. Here, we investigated the sequence feature near the breakpoints in the fusion partner genes, the structure features of breakpoints ...

veterans with post traumatic stress disorder (ptsd) suffer from distressing and disabling symptoms. many studies have shown that ptsd symptoms can negatively influence quality of life of their partners. this study was designed to assess general health, marital satisfaction and self-esteem levels of partners of iranian veterans with ptsd. we performed a case-control study. cases were comprised o...

A blue-fluorescence 2,4,6-tris(4-fluorophenyl)-1,3,5-triazine (TFPT) monomer was synthesized with high yield and high purity under mild reaction conditions. The TFPT, which had three active fluoric groups, was facilely incorporated into stable cross-linked fluorescent polymeric nanoparticles (FCPNs) via precipitation polymerization with 6-(4-hydroxyphenyl)pyridazin-3(2H)-one (HPZ). The FCPNs we...

Fusion genes are frequently observed in hematologic malignancies and soft tissue sarcomas, and are usually associated with chromosome abnormalities. Many of these fusion genes create in-frame fusion transcripts that result in the production of fusion proteins, and some of which aid tumorigenesis. These fusion proteins are often associated with disease phenotype and clinical outcome, and act as ...

Silicatein fusion proteins display comparable silica and ceria biomineralization capabilities regardless of partner or oligomerization status. Therefore, for scalable biomanufacturing, inherent properties the enzyme should be explored.

Abnormalities involving the 14q32 region are recurrent chromosomal changes in plasma cell malignancies. Recent preliminary molecular analyses found IGH rearrangements in almost 100% of human myeloma cell lines and in 75% of patients. However, no systematic study analyzing the nature of the partner chromosomal regions have been reported thus far. To define the exact incidence of illegitimate IGH...

1 Laboratory for Plasmaphysics, Ecole Royale Militaire/Koninklijke Militaire School, EURATOM-Association “Belgian State”, Brussels, Belgium, Partner in the Trilateral Euregio Cluster (TEC) 2 EURATOM-UKAEA Fusion Association, Culham Science Centre, United Kingdom 3 Centre de Recherches en Physique des Plasmas, Association EURATOM, Conférédation Suisse, EPFL, 1015 Lausanne, Switzerland 4 Forschun...

PDGFRB, a transmembrane tyrosine kinase receptor for platelet-derived growth factor, is constitutively activated by gene fusion with different partners in myeloproliferative/myelodysplastic disorders with peculiar clinical characteristics. Six alternative partner genes have been described thus far. In this study, we report the molecular cloning of a novel translocation t(5;17)(q33;p11.2) in a c...

Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia (AL), especially infant and secondary leukemia after previous treatment with DNA topoisomerase II inhibitors. 11q23/MLL abnormalities have been widely recognized as an important prognostic factor in AL. Over 70 chromosome partners of 11q23 have been identified to date, at least 50...