Wnt signaling via the Frizzled (Fz) receptor controls cell polarity and movement during development, but the molecular nature of Wnt/Fz polarity signal transduction remains poorly defined. Here we report that in human cells and during Xenopus embryogenesis, Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture. Wnt/Fz activation of Rho requires the cytopl...

BACKGROUND The frizzled (fz) gene of Drosophila encodes the founding member of the large family of receptors for the Wnt family of signaling molecules. It was originally studied in the adult epidermis, where it plays a key role in the generation of tissue polarity. Mutations in components of the fz signal transduction pathway disrupt tissue polarity; on the wing, hairs normally point distally b...

Many epithelia have a common planar cell polarity (PCP), as exemplified by the consistent orientation of hairs on mammalian skin and insect cuticle. One conserved system of PCP depends on Starry night (Stan, also called Flamingo), an atypical cadherin that forms homodimeric bridges between adjacent cells. Stan acts together with other transmembrane proteins, most notably Frizzled (Fz) and Van G...

Drosophila Frizzled-2 (Dfz2) has been identified as a putative fly Wingless (Wg) receptor. Although Dfz2 shows significant homology with Fz, a protein that operates in the mechanisms that establish planar polarity in Drosophila epithelia, any clear evidence for an involvement by Fz in a Wnt signaling pathway has hitherto been absent. Here we describe the planar polarity phenotypes of loss-of-fu...

In this paper, we introduce two new concepts, generalized ?-?-FZ-contraction and modified ?-?-FZ-contraction, which unify several types of contractions in the context fuzzy metric spaces. We discuss existence uniqueness results such mappings setting a complete space sense George Veeramani present significant consequences our obtained by using variant examples for FZ-simulation functions admissi...

From the INSERM, Centre d’Investigation Clinique CIC-P 9501, Nancy, F-54000 France (RE, RF, FZ, PR) ; CHU Nancy, Department of Cardiology, Nancy, F-54000 France (FZ) ; Université de Lorraine, Nancy, F-54000 France (FZ, PR) ; INSERM, U1116, Nancy, F54000 France (FZ, PR) ; Clermont Université, Université d’Auvergne, UMR6284, F-63000 Clermont-Ferrand France (RE) ; CHU Clermont-Ferrand, Department ...

We have raised antisera against human prothrombin activation fragment Fa in rabbits and have chromatographed the respective immunoglobulin G fractions on prothrombin-Sepharose, Prl-Sepharose, and FZ-Sepharose immunoadsorbents. The specific antibody population obtained was utilized to construct a double antibody radioimmunoassay capable of measuring as little as 0.8 rig/ml of this component. Our...

Background and Aim: Auditory P300 is an event-related potential. Cognitive factors like attention are involved in the generation of P300. It seems that normative variation of P300 is necessary for clinical purposes. Thus, the current study was designed to establish preliminary normative variation of P300 amplitude and latency at Fz and Cz sites in adults. Methods: This cross-sectional study was...