background: neurotransmitter release is an essential link in cell communication of the nervous system. many investigations have focused on gamma amino butyric acid (gaba)-ergic neurotransmission, because it has been implicated in the pathophysiology of several central nervous system disorders. to bypass complications related to homo- and heterosynaptic modulation and to avoid indirect interpret...

Introduction: Paraoxon (the neurotoxic metabolite of organophosphorus (OP) insecticide, parathion) exerts acute toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and hence overstimulation of the cholinergic system. Since, reports on changes in the level of γ- amino butyric acid (GABA) during OP-induced convulsion have bee...

Malus baccata (L.) Borkh. is one of the most widely used rootstocks in apple-producing region Northern China. However, early growing season, apple roots are often subjected to suboptimal low root-zone temperatures. The regulatory effects exogenous γ-aminobutyric acid (GABA) on both shunt (GABA shunt) and respiratory activity under temperatures remain unknown. To explore physiological basis for ...

BackgroundTranscranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) hypothetically modulates cognitive functions by facilitating or inhibiting neuronal activities chiefly in cerebral cortex. The effect of tDCS deeper brain region, basal ganglia-cortical circuit, remains unknown.ObjectiveTo investigate interaction between ?-aminobutyric acid (GABA) concentratio...

El cumplimento de las Guías Alimentarias Basadas en Alimentos (GABA) vigentes Chile, asegura una alimentación suficiente y equilibrada. Objetivo: Determinar el cumplimiento 5 recomendaciones GABA su asociación con variables antropométricas, estilo vida metabólicas, adolescentes que participaron la Encuesta Nacional Salud 2016-2017. Sujetos Método: Estudio transversal incluyó 355 entre 15 a 19 a...

Background: It has been suggested that organophosphates may inhibit gamma-aminobutyric acid (GABA) metabolism in synaptosomal preparations. In the present investigation, we have assessed the interaction between paraoxon and the GABA system at synaptic level. Methods: Synaptosomes were prepared from male Wistar rats (200-250 g). Cerebral cortex was dissected and homogenized, then centrifuged at ...

Background: There are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. According to several studies, elevated serum levels of gamma-amino butyric acid (GABA), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. The purpose of this research was to estimate the effects of curcumi...

The activities of 4-aminobutyric-2-oxoglutaric acid transaminase (GABA-T) and succinate semialdehyde dehydrogenase (SSADH) were determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-X)and/or caerulein (CLN). GABA transaminase activity was measured utilizing endogenous succinate semialdellyde dehydrogenase to convert the product of GAB A-T, succinate semiald...

The contents of GABA, glutamine (Glu) and asparagine (Asp) acids as well as activities of glutamatdecarboxylase (GDK; CF 4.1.1.15) and 4-aminobutirat: 2-oxoglutarataminotransferase (GABA-T: CF 2.6.1.19) in brain cortex, cerebellum, brainstem and hypothalamus under impact of testosterone propionate at a dose of 5 mg/100 g of alive weight of adult albino male rats in spring and autumn were studie...

The cold-sensitive peach fruits are prone to chilling injury (CI). ?-aminobutyric acid (GABA) has been confirmed effectively improve peaches’ cold tolerance. This research aimed probe the role of dynamic changes in membrane lipid metabolism GABA-mediated tolerance and reveal underlying mechanisms based on metabolomics. GABA treatment improved by reducing phosphatidic (PA) accumulation via inhib...