نتایج جستجو برای: gabaergic neuron
تعداد نتایج: 73309 فیلتر نتایج به سال:
Significance Predatory hunting involves measured risk taking by the predator to anticipate dangerous defensive behavior from prey. This a mechanism where motivation hunt can overcome behaviors toward prey unlock attack. Here, we found that activation of subset GABAergic neurons in lateral hypothalamus (LHA) promotes but not feeding behavior. Stimulation projections these periaqueductal gray (PA...
We have studied the effects of GABAergic innervation on the clustering of GABA(A) receptors (GABA(A)Rs) in cultured hippocampal neurons. In the absence of GABAergic innervation, pyramidal cells form small (0.36 +/- 0.01 micrometer diameter) GABA(A)R clusters at their surface in the dendrites and soma. When receiving GABAergic innervation from glutamic acid decarboxylase-containing interneurons,...
Chandelier (or axo-axonic) cells are one of the most distinctive GABAergic interneurons in the brain. Their exquisite target specificity for the axon initial segment of pyramidal neurons, together with their GABAergic nature, long suggested the possibility that they provide the ultimate inhibitory control of pyramidal neuron output. Recent findings indicate that their function may be more compl...
The reversal potential of GABAA receptor channels is known to be less negative than the resting membrane potential under some cases. Recent electrophysiological experiments revealed that a GABAergic unitary conductance with such a depolarized reversal potential could not only prevent but also facilitate action potential generation depending on the timing of its application relative to the excit...
Aim: Bipolar disorder is a multifactorial being linked with dysregulation of several genes. Among the recently acknowledged factors in pathophysiology bipolar are non-coding RNAs (ncRNAs). Methods: We searched PubMed and Google Scholar databases to find studies that assessed expression profile miRNAs, lncRNAs circRNAs disorder. Results: Dysregulated ncRNAs patients have been enriched neuron-rel...
Prenatal stress is associated with altered behavioral, cognitive, and psychiatric outcomes in offspring. Due to the importance of GABAergic systems in normal development and in psychiatric disorders, prenatal stress effects on these neurons have been investigated in animal models. Prenatal stress delays GABAergic progenitor migration, but the significance of these early developmental disruption...
In this modeling study, we show the combined e ects of gap junctions and GABAergic synapses on the synchronous ring in networks of fast-spiking (FS) interneurons. We found analytically that two identical electrically coupled FS interneurons re synchronously at arbitrary ring frequencies, whereas an FS neuron pair coupled through GABAergic synapses show asynchronous ring. Accordingly, an FS neur...
Transplantation of GABAergic interneurons (INs) can provide long-term functional benefits in animal models of epilepsy and other neurological disorders. Whereas GABAergic INs can be differentiated from embryonic stem cells, alternative sources of GABAergic INs may be more tractable for disease modeling and transplantation. We identified five factors (Foxg1, Sox2, Ascl1, Dlx5, and Lhx6) that con...
Establishing and maintaining the appropriate number of GABA synapses is key for balancing excitation and inhibition in the nervous system, though we have only a limited understanding of the mechanisms controlling GABA circuit connectivity. Here, we show that disrupting cholinergic innervation of GABAergic neurons in the C. elegans motor circuit alters GABAergic neuron synaptic connectivity. The...
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