Background: Evaluate the efficacy of using combination drug treatment to relieve post extraction pain impacted mandibular third molar by Naproxen plus Gabapentin versus alone. Aim: To evaluate Methods: Randomized control study, outcome was evaluated measuring Pre – Operative and 24-Hour Post Pain status on Visual Analogue Scale Wong Baker’s Face Rating Scale. Results: Combination therapy (Napro...

background: acute pain is common after arthroscopic surgeries and it is one of the most important causes of patient dissatisfaction, admission time and increased morbidity . gabapentin with anti-hyperalgesic effects can play a critical role in pre-emptive analgesia methods. the aim of this study was to assess the efficacy of gabapentin in pain management after surgery and the rate of drug consu...

objective(s): the present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. materials and methods: oxaliplatin (5 mg/kg) or saline was administered to adult male sprague-dawley rats.  gabapentin (60 mg/kg, ip) or vehicle was injected daily. mechanical allodynia was assessed us...

Gabapentin seems to be a safe and well tolerated medication for treating heroine dependence. This study examined the efficacy of gabapentin for relieving withdrawal-related pain due to heroin use.Sixty men were recruited from an inpatient psychiatric ward of Fatemieh hospital in Semnan and randomized to receive either placebo (n = 30) or gabapentin (1800 mg/day) (n = 30) for 7 days. Subjective ...

Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 neurons was investigated. Pre-treatment with gabapentin reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slic...

BACKGROUND Gabapentin has been reported to inhibit various acute and chronic pain conditions in animals and humans. Although the efficacy of gabapentin depends on the alpha2delta subunit of voltage-gated calcium channels, its analgesic mechanisms in vivo are still unknown. Here, the authors tested the role of spinal noradrenergic inhibition in gabapentin's analgesia for postoperative pain. ME...

G abapentin [1-(aminomethyl)cyclohexane acetic acid] is a structural analog of g-aminobutyric acid (GABA), which was initially introduced in 1994 as an antiepileptic drug (AED), particularly for partial seizures. For a long time, AEDs such as carbamazepine have been recognized as adjunctive drugs for treating certain symptoms of chronic pain syndromes. It is then not surprising that gabapentin ...

BACKGROUND Postherpetic neuralgia (PHN) is a common type of neuropathic pain occurring after resolution of herpes zoster rash. Although gabapentin is a widely used treatment, some disagreements exist about its efficacy and safety. Meta-analysis was performed to better evaluate the efficacy and safety of gabapentin for management of PHN. METHODS Randomized, double-blind, placebo-controlled tri...

Gabapentin has been known to elicit the antinociceptive effect. However, little has been known about the effect of gabapentin on the cardiovascular system. The author's aim of this experiment was to examine the hemodynamic effects of gabapentin. Male Sprague-Dawley rats were used. Intrathecal or intracerebroventricular catheters were implanted and gabapentin was delivered through each catheter ...

BACKGROUND High-altitude headache (HAH) is a hypobaric hypoxia-induced symptom that is commonly experienced by newcomers to high-altitude areas. OBJECTIVE To assess the efficacy of gabapentin in the prevention of HAH. METHODS A placebo-controlled randomised trial was performed at an altitude of 3500 m. Two hundred and four unacclimatised 15-65-year-old (mean age (+/-SD), 31.5 (SD 11.7)) hot...