In January 2013, a 41-year-old man presented for follow-up to our diabetes unit with jaundice, fatigue, dark urine, and stool discoloration. Four weeks earlier, he had suffered a sudden sensorineural hearing loss and was treated with a prednisolone taper scheme starting with 250 mg q.i.d. in addition to a-lipoic acid. Fasting hyperglycemia (274 mg/dL) was detected after initiation of the therap...

Gamma-aminobutyric acid (GABA) is a non-protein amino acid commonly present in all organisms. Because cellular levels of GABA in plants are mainly regulated by synthesis (glutamate decarboxylase, GAD) and catabolism (GABA-transaminase, GABA-T), we attempted seed-specific manipulation of the GABA shunt to achieve stable GABA accumulation in rice. A truncated GAD2 sequence, one of five GAD genes,...

The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. Chronic nicotine exposure increases sensitivity to nicotine reward during a withdrawal period, which may facilitate rel...

BACKGROUND Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene -243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. METHODS Insulin, glucose and lipid lev...