BACKGROUND It has been reported that GLP-1 agonist exenatide (exendin-4) decreases blood pressure. The dose-dependent vasodilator effect of exendin-4 has previously been demonstrated, although the precise mechanism is not thoroughly described. Here we have aimed to provide in vitro evidence for the hypothesis that exenatide may decrease central (aortic) blood pressure involving three gasotransm...

BACKGROUND & AIMS Hydrogen sulphide (H2S), nitric oxide (NO), and carbon monoxide (CO) are involved in transitional microvascular tone dysregulation in the preterm infant; however there is conflicting evidence on the interaction of these gasotransmitters, and their overall contribution to the microcirculation in newborns is not known. The aim of this study was to measure the levels of all 3 gas...

Reactive oxygen species have emerged as key participants in a broad range of physiological and pathophysiological processes, not least within the vascular system. Diverse cellular functions which have been attributed to some of these pro-oxidants within the vasculature include the regulation of blood pressure, neovascularisation and vascular inflammation. We here highlight the emerging roles of...

Gaseous molecules such as nitric oxide (NO), hydrogen sulfide (H₂S), or carbon monoxide (CO) are involved in the regulation of colonic water and salt transport, which can be switched between absorption and secretion. Nitric oxide is produced from the amino acid L-arginine by different isoforms of the enzyme NO synthase, which are expressed both by enteric neurones and by the colonic epithelium....

G asotransmitters, including NO, CO, and H2S, are a group of endogenously produced gas molecules that are membranepermeable and share similar molecular targets (1). Gasotransmitters may antagonize or potentiate each other’s cellular effects at three levels: their production, their downstream molecular targets, and the direct chemical interaction among themselves. The study published in PNAS by ...

1Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, Canada 2Department of Surgery and Department of Microbiology and Immunology, Western University, London, ON, Canada 3Department of Pathophysiology, Nanjing Medical University, Nanjing, China 4School of Life Science, Shanxi University, Taiyuan, China 5Department of Chemistry and Biochemistry, University of Oregon, Eug...