We study energy deposition by light nuclei in tissue-like media taking into account nuclear fragmentation reactions, in particular, production of secondary neutrons. The calculations are carried out within a Monte Carlo model for heavy-ion therapy (MCHIT) based on the GEANT4 toolkit. Experimental data on depth-dose distributions for 135-400 A MeV (12)C and (18)O beams are described very well wi...

Introduction Range and diffusion of positron-emitting radiopharmaceuticals are important parameters for image resolution in positron emission tomography (PET). In this study, GEANT4 toolkit was applied to study positron diffusion in soft tissues with and without a magnetic field for six commonly used isotopes in PET imaging including 11C, 13N, 15O, 18F, 68Ga, and 82Rb. Materials and Methods GEA...

Geant4 is a toolkit for the simulation of the passage of particles through matter. It provides a comprehensive set of tools for geometry, tracking, detector response, run, event and track management, visualization and user interfaces. Geant4 also has an abundant set of physics models that handle the diverse interactions of particles with matter across a wide energy range. However, there are als...

In this paper, we present a novel implementation of a dose calculation application, based on the GEANT4 Monte Carlo toolkit. Validation studies were performed with an homogeneous water phantom and an Alderson-Rando anthropomorphic phantom both irradiated with high-energy photon beams produced by a clinical linear accelerator. As input, this tool requires computer tomography images for automatic...

20 Modelling the radio-induced effects in biological medium requires accurate physics models to 21 describe in detail the main physical interactions induced by all the charged particles present in 22 the irradiated medium (secondary as well as primary ones). These interactions include 23 inelastic events like ionization and excitation processes as well as elastic scattering, the latter 24 being...

Minnae Chabwera: NASA Undergraduate Research Scholar Advisor: Dr. Paul Guèye Institution: Hampton University Hampton, VA 23668 Introduction The research conducted under the guidance of Dr. Paul Guèye involved the construction of a Low Energy Electron Accelerator (LELIA) spearheaded by the Physics Department at Hampton University. The aim of this research has been to reactivate a thermionic gun...

Typically water is used as an analog material for Deoxyribonucleic Acid (DNA) in Monte Carlo simulations of biological radiation interactions. Prior to this work, it was unclear whether water is an appropriate stand-in for DNA when simulating direct radiation damage on the nano scale. The increased interest in targeted tumor therapy using Auger electrons has requires an understand of the radiob...