OBJECTIVE We investigated whether implantation of polylactic acid and epsilon-caprolactone copolymer (PLAC) cubes with or without basic fibroblast growth factor (b-FGF) released slowly from gelatin microspheres was able to induce fibrous tissue in the dead space remaining after pneumonectomy in the thoracic cavity. METHODS Left pneumonectomy was performed in Japanese white rabbits. In the con...

Recent studies have shown that new neurons are continuously generated by endogenous neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain. Some of these new neurons migrate to injured brain tissues and differentiate into mature neurons, suggesting that such new neurons may be able to replace neurons lost to degenerative disease or injury and improve or repair neurologi...

Delivery of growth factors or bioactive molecules plays an important role in tissue engineering, as the duration to which these are supplied can modulate the cell fate. Thus, the delivery method plays an important role, and the same is presented in this work wherein the exogenous supply of alpha-ketoglutarate ( α -KG) gave better results for fast proliferating cells as compared to delivery by m...

BACKGROUND AND PURPOSE Trisacryl gelatin microspheres are a new, commercially available nonabsorbable embolic agent. The purpose of this study was to evaluate their efficacy in the preoperative embolization of meningiomas as compared with polyvinyl alcohol (PVA) particles of various sizes. METHODS In 30 consecutive patients, trisacryl gelatin microspheres (150-300 microm) were used for the pr...

This study evaluated the regenerative effects of platelet-rich plasma (PRP) for the degenerated intervertebral disc (IVD) in vivo. After induction of IVD degeneration in rabbits, we prepared PRP by centrifuging blood obtained from these rabbits. These PRP were injected into the nucleus pulposus (NP) of the degenerated IVDs after impregnation into gelatin hydrogel microspheres that can immobiliz...

Gelatin A microspheres of propranolol hydrochloride for intranasal systemic delivery were developed with the aim to avoid fi rst pass metabolism, to improve the patient compliance, to use an alternative therapy to conventional dosage form, to achieve controlled blood level profi les, and to improve the therapeutic effi cacy of propranolol hydrochloride in the treatment of various cardiovascular...

BACKGROUND Peritoneal carcinomatosis is a poor prognostic factor for patients with gastrointestinal, gynecologic, and pancreatic cancer. Cisplatin (CDDP) is among the most effective anti-cancer agents, although its adverse effects remain unresolved. For the treatment of peritoneal carcinomatosis with high-dose CDDP, it is necessary to design a new delivery system of CDDP that can decrease syste...

nano-hydroxyapatite/gelatin (nha/ge) microspheres are currently used in bone tissue engineering as bone filler. in this  study, the effect of fabrication process parameters on the particle size of nano-hydroxyapatite/gelatinmicrospheres was investigated. the nha/ge microspheres were fabricated using water in oil emulsion. in order to design an experimental design, a surface response model with ...

In this study, pH sensitive microsphere polymeric drug carriers were produced by using biodegradable natural gelatin and sodium alginate polymers. Microspheres loaded with prepared Ganoderma lucidum extract that is a medicinal mushroom has the potential to be used in several diseases’ treatment. Extract release kinetics of microspheres examined spectrophotometric method an UV spectrometer. Buff...