DW-224a is a new broad-spectrum quinolone with excellent antipneumococcal activity. Agar dilution MIC was used to test the activity of DW-224a compared to those of penicillin, ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin, gemifloxacin, amoxicillin-clavulanate, cefuroxime, and azithromycin against 353 quinolone-susceptible pneumococci. The MICs of 29 quinolone-resistant pneumococci wi...

The electrochemical oxidation behavior and voltammetric assay of gemifloxacin were investigated using differential-pulse and cyclic voltammetry on a screen-printed carbon electrode. The effects of pH, scan rates, and concentration of the drug on the anodic peak current were studied. Voltammograms of gemifloxacin in Tris-HCl buffer (pH 7.0) exhibited a well-defined single oxidation peak. A diffe...

Main objective of this present study was to prepare and investigate the different pseudo polymorphic forms of gemifloxacin using Powder X-Ray Diffraction analysis (PXRD), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectrometry (FTIR) and dissolution studies. For this purpose, crystals of gemifloxacin (G-1 to G-4) were obtained by solv...

The ability of sequential subcultures in subinhibitory concentrations of gemifloxacin, trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin to select resistant mutants was studied in 16 pneumococci [eight with ciprofloxacin MICs (mg/L) 0.25-1; four with 8-16; four with 16-32]. Subculturing was done 50 times, or until mutants with elevated MICs (> or = 4 x) to the selecting drug emerged. ...

Correspondence: Cristian Jivcu 1111 east McDowell road, Banner Good Samaritan Medical Center, Deparment of Internal Medicine, Phoenix, AZ, USA Tel +1 602 239 2296 Fax +1 602 239 2084 email [email protected] Abstract: The newest generation of fluoroquinolones have proven efficacy against bacterial organisms associated with acute exacerbation of chronic bronchitis (AECB). Gemifloxacin, as one of t...

In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log(10) [Deltalog(10)] CFU/ml/h, -0.68 +/- 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin (-0.49 +/- 0.09 deltalog(10) CFU/ml/h), in the treatment of meningitis due to a penicillin...

The aim of this study was to establish a correlation between in vitro dissolution and in vivo absorption data of prepared immediate release Gemifloxacin tablets (Zagam) and compare with conventional tablets of Gemifloxacin (Factive). In vitro release data were obtained for test and reference tablets by using the USP apparatus II, 0.01N HCl of pH 2.0 at 50 rpm. A group of six healthy, male human...

objective(s):gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. in this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. materials and methods: three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (ip) for the evaluation o...

The in vitro activity of gemifloxacin was compared to that of other quinolone and nonquinolone antimicrobials against 204 anaerobes by the agar dilution technique. The data indicate that gemifloxacin has a rather selective anaerobic activity. Most Peptostreptococcus, Porphyromonas, and Fusobacterium species are susceptible, while gemifloxacin's activity against other gram-negative anaerobes app...

ABSTRACT: Resistance to the various classes of antimicrobials continues to increase in virtually all clinically significant gram-negative and gram-positive bacteria. In particular, rates of resistance to -lactam and macrolide antimicrobial agents are on the rise among the most common bacterial pathogens, including Streptococcus pneumoniae and Haemophilus influenzae. In the bacterial cell, the f...