The pressure to publish novel genetic associations has meant that meta-analysis has been applied to genome-wide association studies without the time for a careful consideration of the methods that are used. This review distinguishes between the use of meta-analysis to validate previously reported genetic associations and its use for gene discovery, and advocates viewing gene discovery as an exp...

Although each statistical unit on which measurements are taken is unique typically there is not enough information available to account totally for its uniqueness. Therefore heterogeneity among units has to be limited by structural assumptions. One classical approach is to use random effects models, which assume that heterogeneity can be described by distributional assumptions. However, inferen...

Meta-analysis is a standard statistical method used to combine the conclusions of individual studies that are related and the results of single study alone can not answered to deal with issues. The data are summarized by one or more outcome measure estimates along with their standard errors. The multivariate model and the variations between studies are not considered in most articles. Here we d...

This paper sheds some light on the problems associated with random effects gravity approaches. Arguments for the superiority of a fixed effects model are given both along intuitive and econometric lines based on a Hausman test.  2000 Elsevier Science S.A. All rights reserved.

This paper uses data drawn from the English Football League to model separate hazard rates for club managers for the 2001/2, 2002/3 and 2003/4 seasons. On average over the three seasons, approximately one-third of managers involuntarily exited employment status with their club. We model the hazard using a standard logistic model exploiting information on the spell at risk rather than the indivi...

the tlr4 gene structure as the main receptor for lipopolysaccharide recognition of gram-negative bacteria was investigated in two strains of iranian commercial arian line and west azerbaijan native chicks and its expression was studied in some major organs. blood samples of the 120 birds were taken and total dnas extracted. then, the target gene was sequenced using four pairs of primers on four...