The understanding of non-random association between loci, termed linkage disequilibrium (LD), plays a central role in genomic research. Since causal mutations are generally not included in genomic marker data, LD between those and available markers is essential for capturing the effects of causal loci on localizing genes responsible for traits. Thus, the interpretation of association studies re...

x-acetylaminofiuorene N-hydroxy-2-acetylamino fluorene x-hydroxy-2-acetylamino fluorene 2-hydroxylaminonaphthalene Recently it has become apparent that an increasing number of carcinogens are capable of interacting with nucleic acids (10, 14, 923). These observations may be causally related to the mech anism of carcinogenesis as being a special case of mutagenesis. The chemical reactions of som...

A disintegrin and metalloprotease 9 has been reported to play a key role in many diseases. However, the underlying effects mechanisms of alcoholic liver fibrosis have not well understood. To investigate its regulatory molecular mechanism fibrosis, single guide ribonucleic acid targeting sequence mice was adopted by clustered regularly interspaced short palindromic repeats/Cas9 technology inhibi...

Reactive oxygen metabolites can pro­ mote carcinogenesis by damaging DNA. vi­ tamin C is a redox chemical with antioxi­ dant and pro-oxidant properties that may produce radical species depending on the presence of various conditions. Nevertheless, evidence presented herein discourages the consideration of any mutagenic or carcino­ genic activity of vitamin C. In contrast, it substantiates a pro...

A comparative study of genic allozyme and chromosomal polymorphisms in four continental (South American) and six oceanic island (West Indies) populations of Drosophila willistoni has been made. The pattern of genic polymorphism is closely similar in all populations. Although regional and local differences in gene frequencies are found, generally the same alleles occur at high, intermediate, and...

The frequency and distribution of microsatellites were analyzed in the 19 mitogenomes of phytopathogenic fungi covering five phyla. Our analysis revealed that in all the mitogenomes studied, the frequency and relative abundance varied, and it was neither influenced by genome size nor by GC content. SSRs were found to be differential distributed in genic and intergenic regions. An average of 5.1...

MOTIVATION Simple sequence repeats (SSRs) are abundant across genomes. However, the significance of SSRs in organellar genomes of rice has not been completely understood. The availability of organellar genome sequences allows us to understand the organization of SSRs in their genic and intergenic regions. RESULTS We have analyzed SSRs in mitochondrial and chloroplast genomes of rice. We ident...