An in silico study was conducted to inhibit the active compound Kirinyuh leaves (Chromolaena odorata L.) against α-amylase and α-glucosidase enzymes using a molecular docking approach. The carried out on 19 compounds that had been identified were optimized PM3 method. best results of enzyme shown by from flavanone group, namely genkwanin sakuranetin with binding affinities -8.3 kcal/mol -8.1 kc...

The bark of Prunus jamasakura Siebold (Pruni Cortex) has long been used in Japan as a folk remedy and is one of ingredients of the Kampo formula, Jumi-haidoku-to (JHT). JHT is used for treatment of skin diseases such as acne (acne vulgaris). According to Kampo medicinal sources, Quercus Cortex can be used in place of Pruni Cortex. In this study, we found that water extracts of Pruni Cortex, not...

Apigenin, a widely distributed flavone, exhibits excellent antioxidant, anti-inflammatory, and antitumor properties. In addition, the methylation of apigenin is generally considered to result in better absorption and greatly increased bioavailability. Here, four putative Class II methyltransferase genes were identified from the transcriptome sequences generated from the liverwort species Plagio...

To assess possible effects of genkwanin (GKA) in septic lung injury and its related mechanisms. An animal model cecal ligation puncture (CLP)-induced acute was constructed. Histological analysis wet–dry (W/D) ratio the tissue were observed. The cell apoptosis this analyzed by caspase activity detection, protein levels B-cell lymphoma 2 (Bcl-2) Bcl-2-associated X (Bax), inflammation CLP model; a...

Hyptis pectinata, popularly known in Brazil as "sambacaitá" or "canudinho," is an aromatic shrub largely grown in the northeast of Brazil. The leaves and bark are used in an infusion for the treatment of throat and skin inflammations, bacterial infections, pain, and cancer. Analogues of rosmarinic acid and flavonoids were obtained from the leaves of Hyptis pectinata and consisted of two new com...