GOLD is a comprehensive resource for accessing information related to completed and ongoing genome projects world-wide. The database currently provides information on 350 genome projects, of which 48 have been completely sequenced and their analysis published. GOLD was created in 1997 and since April 2000 it has been licensed to Integrated Genomics. The database is freely available through the ...

The ordering of genes in a genome can be changed through rearrangement events such as reversals, transpositions and translocations. Since these rearrangements are “rare events”, they can be used to infer deep evolutionary histories. One important problem in rearrangement analysis is to find the median genome of three given genomes that minimizes the sum of the pairwise genomic distance between ...

Gene rearrangements have been used successfully in phylogenetic reconstruction and comparative genomics, but usually under the assumption that all genomes have the same gene content and that no gene is duplicated. While these assumptions allow one to work with organellar genomes, they are too restrictive for nuclear genomes. The main challenge in handling more realistic data is how to deal with...

cernible. The peroxidase technique also permits the specimen to be examined by electron microscopy. Perhaps a few too many chapters are devoted to individual applications of the technique, but it is an exciting development in diagnostic virology. Viral genomes can be present in cells without full expression leading to the production of viral antigens or virions which can be detected by immunolo...

The objective function of the genome rearrangement problems allows the integration of other genome-level problems so that they may be solved simultaneously. Three examples, all of which are hard: 1) Orientation assignment for unsigned genomes. 2 ) Ortholog identification in the presence of multiple copies of genes. 3) Linearisation of partially ordered genomes. The comparison of traditional gen...

Three newly discovered species of fig-living nematodes display remarkable diversity in head morphology depending on their local environment. This shows that a great deal of ecological diversity can be maintained in the absence of substantial genetic variation.

Combining well-established practices from comparative genomics and the emerging opportunities from assembly-based metagenomics can enhance the utility of increasing number of metagenome-assembled genomes (MAGs). Here we used protein clustering to characterize 48 MAGs and 10 cultivars based on their entire gene content, and linked this information to their environmental distribution patterns to ...

Tomato production in the Mediterranean region and elsewhere is under constant threat of the whitefly-transmitted begomoviruses that cause Tomato yellow leaf curl disease (TYLCD). Sequencing has indicated that the generic ‘TYLCV’ includes a large number of viruses and strains. We studied the distribution of the tomato yellow leaf curl disease-associated viruses in Egypt, Israel, Jordan and Leban...

The Genomes On Line Database (GOLD) is a comprehensive resource that provides information on genome and metagenome projects worldwide. Complete and ongoing projects and their associated metadata can be accessed in GOLD through pre-computed lists and a search page. As of September 2007, GOLD contains information on more than 2900 sequencing projects, out of which 639 have been completed and thei...