نتایج جستجو برای: genomic
تعداد نتایج: 115648 فیلتر نتایج به سال:
The aim of this study was to determine the effect of marker density, level of heritability, number of QTLs, and size of training set on the genomic accuracy over three generations. Thereby, a trait was simulated with heritability of 0.10, 0.25 or 0.40. For each animal, a genome with 20 chromosomes, 1 Morgan each, was simulated. Different marker densities (2000, 4000 and 6000 markers) and 400 an...
Over the past decades, progression in genetic element manipulation, and consequently, the treatment of diseases has been remarkable. It is worth noting that these genetic manipulations perform at different levels, including DNA and RNA. The earlier genomic editing techniques, including MN, ZFN , TALEN , performing their functions by creating double-stranded breaks (DSBs), and after breakage, th...
nutrigenomics applies genomic technologies to study how nutrients affect expression of genes. with the advent of the post genomic era and with the use of functional genomic tools, the new strategies for evaluating the effects of nutrition on production efficiency and nutrient utilization are becoming available. nutrigenomics plays an efficient role in various fields of animal health like nutrit...
Purpose: Several causes for primary ovarian insufficiency have been described, including iatrogenic and environmental factor, viral infections, chronic disease as well as genetic alterations. Given the large number of genes described in the literature so far, the aim of this review was to collect all the genetic mutations associated with non-syndromic primary ovarian insufficiency. Methods: All...
Genomic selection combines statistical methods with genomic data to predict genetic values for complex traits. The accuracy of prediction of genetic values in selected population has a great effect on the success of this selection method. Accuracy of genomic prediction is highly dependent on the statistical model used to estimate marker effects in reference population. Various factors such a...
selective signatures in whole genome can help us to understand the mechanisms of selection and to identify the genomic regions that have been under natural or artificial selection during long years. the objective of this study was to identify the genomic regions that have been under artificial and natural selection in baluchi and zel sheep breeds. 143 sheep from baluchi (n=96) and zel breeds (n...
the objective of this study was to compare six statistical methods for prediction of genomic breedingvalues for traits with different genetic architecture in term of gene effects distributions and number ofquantitative traits loci (qtls). a genome consisted of 500 bi-allelic single nucleotide polymorphism(snp) markers distributed over a chromosomes with 100 cm length was simulated. three differ...
BackgroundKi67 immunohistochemistry (IHC) with a cut-off of 20% by MIB-1 PharmDx assay has been approved as companion diagnostic for adjuvant abemaciclib in high-risk ER+HER2- breast cancer. We addressed the genomic risk profile high Ki67 (≥20%) cancer using 21-gene multigene (Oncotype DX test). In addition, we investigated survival outcomes and identified factors associated low group.MethodsWe...
introduction: genomic selection refers to selection decisions based on genomic breeding values (gebv). the gebv are calculated as the sum of the effects of dense genetic markers across the entire genome, thereby potentially capturing all the quantitative trait loci (qtl) that contribute to variation in a trait. the qtl effects, inferred from markers, are first estimated in a large reference pop...
Genomic DNA extraction with a high quantity and quality is a basic requirement in molecular biology. The DNA obtained was free of any contamination proteins, polysaccharide, polyphenols and colored pigments. These compounds would interfere with the genomic isolation procedures and downstream reactions such as restriction enzyme analysis and gene amplification. The isolated genomic DNA was fo...
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