Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm composed of intermediate trophoblasts. Most cases of ETT are reported in women of reproductive age following a prior gestation within 2 weeks to 30 years. ETT is extremely rare in postmenopausal women. It is commonly misdiagnosed as a poorly differentiated carcinoma or another type of gestational trophoblastic tu...

background : gestational trophoblastic neoplasia (gtn) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. many attempts have been made to improve follow-up procedures, but no studies have evaluated human chorionic gonadotrophin (hcg) as a post treatment indicator. thus we aimed to know β-hcg variability in post treatment pregnancies.   method...

•Gestational trophoblastic neoplasia observed distant from antecedent pregnancy•Pneumothorax is a rare presentation of intermediate trophoblastic tumors.

Background—The p21 gene mediates growth arrest by inhibiting G1 cyclin dependent kinases and has been considered as a downstream eVector of the tumour suppressor gene p53. Aim—To analyse the role of p21 in gestational trophoblastic disease. Methods—The immunohistochemical expression of p21 gene was measured in 33 placentas, 28 partial hydatidiform moles, 54 complete hydatidiform moles, and 13 c...

Invasive mole is a benign gestational trophoblastic disease that arises from the myometrial invasion of any gestational event via direct extension through tissue or vascular structures. Invasive mole (and other gestational trophoblastic diseases) may present with life-threatening complications including uterine perforation, excessive bleeding, acute hemoperitoneum, and abdominal pain. We report...

estational trophoblastic disease includes following forms of growth disturbance of the human trophoblast: hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumors. Term gestational trophoblastic disease is applied to the letter three conditions. Diagnosis and decision to institute treatment are sometimes undertaken without histopathological finding. Gestational tr...

The authors present the computed tomographic findings in a patient with malignant gestational trophoblastic neoplasia. No similar case has been described on computed tomography. The interesting aspects of the case and a brief review of this clinical entity is discussed. Pelvic computed tomography Ovary Malignant gestational trophoblastic neoplasia Theta-lutein cysts

M. J. Seckl1, N. J. Sebire2, R. A. Fisher1, F. Golfier3, L. Massuger4 & C. Sessa5, on behalf of the ESMO Guidelines Working Group* Department of Cancer Medicine; Department of Histopathology, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College London, London, UK; Centre de Référence des Maladie Trophoblastiques, Hospices Civils de Lyon, Lyon...

Gestational trophoblastic disease corresponds to cystic degeneration of the trophoblast villi with excessive secretion choriogonatrophinic hormone (HCG), groups together lesions : · Benign known as hydatidiform moles (partial or complete) Malignant gestational tumors (GTT), comprising o Choriocarcinomas Invasive Trophoblastic implantation site (TTSI) Diagnosis is based on questioning and clinic...

It is universally recognized that an accurate and precise staging and classification system for gestational trophoblastic neoplasia (GTN) is essential to enable clinicians to assess the prognosis or the risk of patients, to individualize and to optimize their treatment. There have been a variety of staging and classification systems developed by different centres and some are still being used. ...