Two clones that contain goat growth hormone (gGH) genes were isolated from goat genomic library using goat growth hormone cDNA as a probe. One clone CgGH contained gGH1 gene, and another clone, EgGH, contained gGH2 and gGH3 genes. The clone EgGH contained 491 bp inserted sequence, just upstream of the gGH3 gene, which was not present in the clone CgGH. From the sequencing data of the flanking r...

Production of iron-chelating peptides from protein hydrolysates requires robust and adequate screening methods to optimize their purification subsequently valorize potential antioxidant properties. An original methodology was developed for direct sensitive iron(II)-chelating based on ion-pair reverse phase liquid chromatography (IP-RPLC) coupled high-resolution mass spectrometry (HRMS). Peptide...

We construct an Identity-Based Key Encapsulation Mechanism (IBKEM) in a generic “leveled” multilinear map setting and prove its security under multilinear decisional Diffie-Hellmanin assumption in the selective-ID model. Then, we make our IB-KEM translated to the GGH framework, which defined an “approximate” version of a multilinear group family from ideal lattices, and modify our proof of secu...

PURPOSE The purpose of this study was to analyze whether gene expression levels of folate enzymes in adjacent mucosa were associated with outcome of colorectal cancer patients. EXPERIMENTAL DESIGN Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and t...

Multilinear map is a novel primitive which has many cryptographic applications, and GGH map is a major candidate of K-linear maps for K > 2. GGH map has two classes of applications, which are respectively applications with public tools of encoding and with hidden tools of encoding. In this paper we show that applications of GGH map with public tools of encoding are not secure, and that one appl...

Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway. Correlations between polymorphisms and pharmacokinetic parameters and the occurrence of hepato- and myelotoxicity were studied. Single nucleotide polymorphisms (SNPs) of the ABCB1, ABCC1, ABCC2, ABCC3, ABCC10, ABCG2, GGH, SLC19A1 and...

We improve the zeroizing attack on the multilinear map of Garg, Gentry and Halevi (GGH). Our algorithm can solve the Graded Decisional Diffie-Hellman (GDDH) problem on the GGH scheme when the dimension n of the ideal lattice Z[X]/(X+1) is O(κλ) as suggested for the κ-linear GGH scheme. The zeroizing attack is to recover a basis of an ideal generated by a secret element g ∈ Z[X]/(X + 1) from the...

The growth hormone gene could be an attractive candidate gene for milk production in goats. Single-strand conformation polymorphism was used to identify polymorphism at the goat growth hormone (gGH) gene. For this purpose, genotyping of 90 Talli goat breeds was performed. Nine conformational patterns were observed in exon 4 of the gGH gene, with frequencies of 27.7% for the homozygous pattern (...

INTRODUCTION The differences in drug efficacy and adverse reactions may be caused by genetic variations in drug metabolism between individuals. OBJECTIVES The aim of the study was to evaluate the effect of gene polymorphisms on the efficacy of therapy and side effects in patients with rheumatoid arthrit s (RA) treated with methotrexate (MTX). PATIENTS AND METHODS A total of 273 Caucasian pa...

The reduced folate carrier (RFC), a bidirectional anion transporter, is the major uptake route of reduced folates essential for a spectrum of biochemical reactions and thus cellular proliferation. However, here we show that ectopic overexpression of the RFC, but not of folate receptor alpha, a high affinity unidirectional folate uptake route serving here as a negative control, resulted in an ap...