The functioning of the growth hormone (GH) and reproductive axis is known to be closely related: both GH overexpression and GH-deficiency are associated with dramatic decreases in fertility (Bartke, 1999; Bartke et al, 1999; 2002; Naar et al, 1991). Also, aging results in significant changes in functionality of both axes within a similar time frame. In the rat, GH secretion patterns are clearly...

The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH. With GH receptors on virtually all cells, replacement therapy should achieve the same tissue distribution and effects of daily (and endogenous) GH while maintaining levels of GH ...

Beef production is an important development area in animal breeding with meat quality being determined by both paratypic and genetic factors. In this regard evaluating genetic material for the presence of desirable allele combinations of genes associated with growth and development indicators, as well as meat qualities of animals have a certain scientific and practical significance. The aim of ...

It is now established that the lung is a target site for pituitary growth hormone (GH) action, because pathophysiological states of pituitary GH excess and deficiency are associated with impaired pulmonary function. The onset of lung development and differentiation is, however, before the ontogenic differentiation of pituitary somatotrophs. GH may be involved, nevertheless, in lung development,...

The Siberian sturgeon (Acipenser baerii) is an economically important species. Sturgeon stockassessment during fingerling production is considered to be one of the most difficult phases ofhatchery rearing. The present study investigated the expression of growth hormone (GH)mRNA in unfertilized eggs, fertilized eggs, eyed eggs (2 day before hatching), non-viable eggsand newly-hatched Siberian st...

GH is involved in growth and development in vertebrates [1]. The actions of GH are initiated by its binding to the specific GH-receptors (GH-R) localized in the cell membrane of target tissues [2]. GH also binds to a soluble GH-binding protein (GH-BP) in serum [3]. The GH-BP is generated from a variant mRNA resulting from an alternative splicing of GH-R mRNA precursor at the exon 7-8 boundary [...