Methods: Demographic, pharmacological, and periodontal data were obtained from 100 users of the Brazilian Primary Health Care System in Diamantina, Jequitinhonha Valley, Minas Gerais state, Brazil, who were taking nifedipine and/or phenytoin. Clinical evaluations including gingival overgrowth analysis were carried out by a single calibrated examiner. Bivariate analysis (Chi-square test or Stude...

Background: Among anti-hypertension drugs, calcium (Ca) antagonists cause gingival overgrowth as a side effect. We previously discovered that this side effect was due to elevation of the calcium concentration in the cytosol ([Ca]i). Ca entry through non-selective cation channels (NSCCs) and Ca release from intracellular Ca stores are involved in this [Ca]i elevation. Furthermore, we discovered ...

cyclosporine is a selective immunosuppressant that has a variety of applications in medical practice. like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. this review considers the pharmacokinetics, pharmacodynamics, and unwanted effects of cyclosporine, in particular the action of the drug on the gingival tissues. in addition, elucidates the current...

The prevalence of gingival overgrowth secondary to the administration of cyclosporin (CS) is currently reported between 8 and 70%, depending upon the source. Information concerning pediatric patients is limited. To determine the prevalence of the condition in a population of children, 26 pediatric liver or kidney transplant recipients were evaluated for the presence of overgrowth related to CS ...

INTRODUCTION Many factors can contribute to the development of gingival overgrowth (hyperplasia), including: plaque control; periodontal variables; medications and their relative dose; age; sex; and, genetic factors. Nifedipine is a calcium channel blocker commonly reported to result in drug-induced gingival overgrowth (DIGO). This report outlines a case of gingival overgrowth induced by amlodi...

Background: It has been proven that the antihypertensive agent nifedipine can cause gingival overgrowth as a side effect. The aim of this study was to analyze effects pharmacological treatment with on human fibroblasts activity, investigating possible pathogenetic mechanisms lead onset enlargement. Methods: expression profile 57 genes belonging “Extracellular Matrix and Adhesion Molecules” path...

background: gingival overgrowth is a common side-effect of amlodipine regimen on the oral cavity. there is controversy regarding the cause and effect relationship of periodontal health and drug induced gingival overgrowth. therefore, this study was conducted to investigate and to assess the relationship between the periodontal health and the onset and severity of gingival overgrowth in hyperten...