AIMS This study was conducted to evaluate the dose ratio of insulin detemir and neutral protamine Hagedorn (NPH) insulin over a range of therapeutically relevant subcutaneous doses. METHODS The study was a randomized, double-blind, crossover 24-h-iso-glycemic clamp trial in 12 C-peptide-negative type 1 diabetic patients. Each subject received, by an incomplete block design selection, two of t...

OBJECTIVE The objective of the study was to evaluate pharmacodynamic (PD) intrasubject variability of a single, s.c. dose of insulin lispro protamine suspension (ILPS) compared with insulin glargine in subjects with type 1 diabetes mellitus and additionally, to compare the intrasubject variability of pharmacokinetic parameters of both insulins. DESIGN This was a single-center, investigator-bl...

AIMS/INTRODUCTION Insulin degludec/insulin aspart (IDegAsp) is a soluble co-formulation of long-acting insulin degludec (IDeg) and rapid-acting insulin aspart (IAsp). The present study investigated the pharmacodynamic properties of IDegAsp in Japanese patients with type 1 diabetes mellitus. MATERIALS AND METHODS In this randomized, double-blind, two-period, cross-over trial, 21 Japanese patie...

introduction & objective: considering the importance of reproductive health and in order to determine the knowledge of girl high school students about several aspects of reproductive health the present study was done. materials & methods: using cluster random sampling, 546 questionnaires were filled in eight high schools in shiraz. results: the results showed that these adolescents have accepta...

Most geographical information retrieval (GIR) systems separate the treatment of the geographical and the non-geographical part, often called “thematic”. In this paper, we provide an overview of this practice, and we advance arguments for and against. We also show some experimental results that apparently substantiate the non-separation argument. We conclude with the recommendation that this pra...

The most common kind of collections for GIR so far are the Web and other document collections, which are mainly textual. This paper is concerned with the non-trivial relationship between reference to place in natural language (NL) and common GIR assumptions. There are two main ways in which NL texts and GIR meet: in the attempt to derive or populate geo-ontologies from text itself, and in the a...

Insulin responsiveness to glucose and tissue responsiveness to insulin, using the hyperglycemic clamp and the hyperinsulinemic euglycemic clamp techniques, were measured in lactating, late pregnant, and nonpregnant, nonlactating (NPNL) beef cows. The glucose infusion rate (GIR) in the hyperglycemic clamp technique was higher (P less than .05). in lactating cows than in NPNL cows. The plateau in...

OBJECTIVE Clinicians who treat children with type 1 diabetes often try to minimize the number of daily injections to reduce treatment burden and improve compliance. Despite the manufacturer's cautions against mixing glargine with rapid-acting insulin analogs, clinical studies have failed to demonstrate deleterious effects of mixing on glucose excursions or A1C levels. However, no formal glucose...

Almost all available literature correlations to predict the volumetric gas /liquid mass transfer coefficient, kLa in agitated reactors are systemsor operating conditions-dependent. In this study, two back-propagation neural networks (BPNNs), one dimensional and one dimensionless were developed to correlate kLa for numerous gas /liquid systems in both surface-aeration reactors (SAR) and gas-indu...

The time course of insulin sensitivity, skeletal muscle glycogen and GLUT4 content, and glycogen synthase (GS) activity after a single bout of intense exercise was examined in eight horses. On separate days, a euglycemic-hyperinsulinemic clamp (EHC) was undertaken at 0.5, 4, or 24 h after exercise or after 48 h of rest [control (Con)]. There was no increase in mean glucose infusion rate (GIR) w...