نتایج جستجو برای: glial tumors
تعداد نتایج: 197390 فیلتر نتایج به سال:
BACKGROUND Improvements in brain tumor treatments have led to an increase in the number of young women with brain tumors who are now considering pregnancy. The aim of this study is to evaluate the influence of pregnancy on brain tumor biology. METHODS In this institutional review board-approved retrospective study, we searched the institution's database for patients with glial brain tumors wh...
Primary brain tumors consist are a heterogenic group of malignancies. Gliomas represent subtypes which include all tumors arising from glial cells. The risk factors for gliomas are until today unclear. The aim of this study was to summarize all possible connections between suspected risk factors and glial brain tumors.
Objective: Neuronal and Mixed Neuronal-glial Tumors of the Central Nervous System are frequently encountered in the neurosurgical practice. Differentiation of neuronal tumors from the more common glial tumors is crucial because neuronal tumors have favorable clinical outcomes and are generally curable with total surgical resection alone, whereas gliomas typically require further chemoradiothera...
PURPOSE AND EXPERIMENTAL DESIGN The contributions of O6-methylguanine-DNA-methyltransferase(MGMT), p53 status, mismatch repair, and apoptotic response to the resistance of glial tumors to temozolomide (TMZ) were tested using seven established human glial tumor cell lines in culture and xenografts in athymic mice. RESULTS Resistance to TMZ was only marginally dependent on MGMT activity, becaus...
There is growing evidence and a consensus in the field that most pediatric brain tumors originate from stem cells, of which radial glial cells constitute a subtype. Here we show that orthotopic transplantation of human radial glial (RG) cells to the subventricular zone of the 3rd ventricle--but not to other transplantation sites--of the brain in immunocompromised NOD-SCID mice, gives rise to tu...
OBJECTIVE Malignant glial tumors are associated with cerebral edema. The aquaporins (AQPs) are a family of membrane proteins that provide a major pathway for water transport in mammals. In the central nervous system, AQP1 is selectively expressed in the choroid plexus and thought to participate in cerebrospinal fluid production. Prior studies have suggested that AQP1 may be up-regulated in glia...
INTRODUCTION Glial tumors are the most common primary brain tumors. They are derived from astrocytes, oligodendroglial cells, and ependyma. The majority of glial tumors are malignant, and the median survival of patients with glioblastoma is between 12 and 24 months. Improvement in the outcome of patients will depend on a better understanding of the scientific basis of gliomagenesis and the tran...
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