OBJECTIVES Cystatin C is emerging as an endogenous marker of glomerular filtration rate. This study sought to assess the usefulness of serum cystatin C as a marker of glomerular filtration rate in comparison with serum creatinine and serum creatinine-based glomerular filtration rate estimations in voluntary kidney donors. MATERIALS AND METHODS Serum cystatin C and serum creatinine were estima...

The formation of urine is a process that begins with glomerular filtration and is greatly influenced by changes in renal hemodynamics. Selective filtration of the blood is possible because of the unique characteristics of the glomerulus and renal circulation. Many factors interact to maintain a consistent blood flow allowing filtration and urine formation to continue despite systemic changes in...

BACKGROUND AND OBJECTIVES The level of glomerular filtration rate at which hemoglobin declines in chronic kidney disease is poorly described in the pediatric population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This cross-sectional study of North American children with chronic kidney disease examined the association of glomerular filtration rate, determined by the plasma disappearance of...

To determine the validity of endogenous creatinine clearance as a measure of glomerular filtration rate in patients with renal disease 308 simultaneous determinations of inulin clearance and endogenous creatinine clearance were reviewed and analysed. The ratio of creatinine clearance/inulin clearance increased progressively with the decline in inulin clearance, while the finding of a normal end...

The recent article about estimated glomerular filtration rate (GFR) by Levey and colleagues (1) is remarkable. The authors suggest that the new equation may still have some bias and especially may have less precision in patients with GFRs greater than 60 mL/min per 1.73 m 2 . This is even more important if the GFR is greater than 90 mL/min per 1.73 m 2 . In the paper's Methods section, Levey an...

chronic kidney disease (ckd) is an increasing cause of morbidity and mortality worldwide. prospective data on risk factors for ckd are few. hypertension is one of the risk factors for ckd. in the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(gfr), which limits its ability to detect impaired kidne...

The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for J...

Endogenous creatinine clearance was assessed by inulin in 91 simultaneous studies in 41 patients and proved an accurate measurement of glomerular filtration rate. For filtration rates <20 ml/min the creatinine clearance may slightly overestimate the glomerular filtration rate. Successive determinations of filtration rate by either method may vary by 20% even though the methods agree with each o...