BACKGROUND AND OBJECTIVES The level of glomerular filtration rate at which hemoglobin declines in chronic kidney disease is poorly described in the pediatric population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This cross-sectional study of North American children with chronic kidney disease examined the association of glomerular filtration rate, determined by the plasma disappearance of...

OBJECTIVE This study sought to determine the serum aminotransferase levels of patients with predialysis chronic kidney disease and establish their relationships with serum creatinine levels and glomerular filtration rate. METHODS Patients with chronic kidney disease were evaluated between September 2011 and May 2012. Aminotransferase and creatinine serum levels were measured using an automate...

Insulin resistance-related disorders such as type 2 diabetes mellitus (T2DM) and obesity have reached epidemic proportions in the recent years [1]. Diabetic nephropathy (DN) is the number one cause of end-stage renal failure [2]. The pathogenesis of DN perhaps occurs in two major stages: First, there is a vasodilation in the preand post-glomerular arterioles, which leads to higher intra-glomeru...

Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...

Protein A-gold immunocytochemistry was applied in combination with morphometrical approaches to reveal the alpha 1(IV), alpha 2(IV), and alpha 3(IV) chains of type IV collagen as well as entactin on renal basement membranes, particularly on the glomerular one, during maturation. The results have indicated that a heterogeneity between renal basement membranes appears during the maturation proces...

conclusions fasting in the month of ramadan in two consecutive years, and during the hottest months, in riyadh, saudi arabia, did not adversely affect kidney graft function. objectives to investigate the effect of repeated ramadan fasting during the hottest months of the year on renal graft functions. patients and methods this was a prospective cohort study comparing two groups of renal transpl...

BACKGROUND Hyperkalemia is one of the more serious complications of chronic kidney disease (CKD), and the cause of potassium retention is a reduction in urinary potassium excretion. However, few studies have examined the extent of the decrease of urinary potassium excretion in detail with respect to decreased renal function. METHODS Nine hundred eighty-nine patients with CKD (CKD stages G1 an...

Diabetes is the main cause for diabetic kidney disease (dkd), which affects filtering units of kidneys slowly and stops it’s function finally. This consequence common both genetic based (type 1) lifestyle 2) diabetes. However, type 2 diabetes plays a significant influence in increased urine albumin excretion, decreased glomerular filtration rate (gfr), or both. These causes failure stage by sta...

The mechanical properties of tissues and cells including renal glomeruli are important determinants of their differentiated state, function, and responses to injury but are not well characterized or understood. Understanding glomerular mechanics is important for understanding renal diseases attributable to abnormal expression or assembly of structural proteins and abnormal hemodynamics. We use ...