نتایج جستجو برای: glomerulus
تعداد نتایج: 2389 فیلتر نتایج به سال:
The axons of many olfactory receptor cells converge on an individual glomerulus in the olfactory bulb, where they make contacts with the distal dendrites of mitral and tufted cells. Each glomerulus is targeted by olfactory receptor neurons expressing a single type of olfactory receptor protein. The glomerulus provides a unique model in which the function of a cortical module can be unambiguousl...
In rat olfactory bulb slices, external tufted (ET) cells spontaneously generate spike bursts. Only ET cells affiliated with the same glomerulus exhibit significant synchronous activity, suggesting that synchrony results mainly from intraglomerular interactions. The intraglomerular mechanisms underlying their synchrony are unknown. Using dual extracellular and patch-clamp recordings from ET cell...
To gain molecular insight into kidney function, we performed a high-resolution quantitative analysis of gene expression in glomeruli and nine different nephron segments dissected from mouse kidney using Serial Analysis of Gene Expression (SAGE). We also developed dedicated bioinformatics tools and databases to annotate mRNA tags as transcripts. Over 800,000 mRNA SAGE tags were sequenced corresp...
According to the combinatorial receptor and glomerular codes for odors, the fine tuning of the output level from each glomerulus is assumed to be important for information processing in the olfactory system, which may be regulated by numerous elements, such as olfactory nerves (ONs), periglomerular (PG) cells, centrifugal nerves and even various interneurons, such as granule cells, making synap...
Antenna lobe (AL) in the Drosophila brain is composed of ~50 glomeruli. Each of the glomeruli has a stereotyped shape, position, and neuronal composition. However, manually identification of the glomeruli usually is very time consuming and demands high familiarity with the structure. In this project, we applied Principle Component Analysis method via Singular Value Decomposition to identify a s...
Glomerular diseases are common and important. They can arise from systemic inflammatory or metabolic diseases that affect the kidney. Alternately, they are caused primarily by local glomerular abnormalities, including genetic diseases. Both intrinsic glomerular cells and leukocytes are critical to the healthy glomerulus and to glomerular dysregulation in disease. Mesangial cells, endothelial ce...
An in vitro model of the human kidney glomerulus - the major site of blood filtration - could facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-chip technology has been used to model the human proximal tubule, yet a kidney-glomerulus-on-a-chip has not been possible because of the lack of functional human podocytes - the cells that regulate selective per...
After enjoying Kettritz’s and Luft’s Nephroquiz [1], I enjoyed even more their reply [2] to my comment, which they ended by posing an interesting dilemma: should we use the terms ‘glomerulus/glomeruli’, masculine gender, or ‘glomerulum/glomerula’, neutral gender? Though I am not a learned scholar (only relying on my four-year high school Latin, long forgotten), I have done some homework and del...
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