نتایج جستجو برای: gluconeogenesis
تعداد نتایج: 3670 فیلتر نتایج به سال:
Hepatocytes isolated from male dairy calves were used in monolayer culture or in suspension culture to determine their suitability for the study of hormonal regulation of hepatic gluconeogenesis. The rate of gluconeogenesis (nanomoles of 2.5 mM [2-14C]propionate incorporated into glucose.microgram of DNA-1.hour-1) was higher for monolayers than for suspension cultures. Gluconeogenesis and ureag...
Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates gluconeogenesis. Low Nur77 expression in clinical HCC samples correlates with poor prognosis, and a Nur77 deficiency in mice promotes HCC development. Nur77 interacts with phosphoenolpyruva...
Hepatic gluconeogenesis during fasting results from gluconeogenic gene activation via the glucagon-cAMP-protein kinase A (PKA) pathway, a process whose dysregulation underlies fasting hyperglycemia in diabetes. Such transcriptional activation requires epigenetic changes at promoters by mechanisms that have remained unclear. Here we show that GCN5 functions both as a histone acetyltransferase (H...
In hepatocytes from 1-day-old rats, active gluconeogenesis occurs in parallel with active ketogenesis, although the carbon atoms of non-esterified fatty acids do not participate in glucose synthesis. Once a significant ketogenesis is established, a further increase does not enhance gluconeogenesis. Indeed, octanoate is more ketogenic than oleate, but stimulates gluconeogenesis to a similar extent.
1. In incubated tubule fragments from renal cortex of fed rats gluconeogenesis from pyruvate was stimulated by adrenaline (1 pM optimum) and by the selective a-adrenergic agonists oxymetazoline and amidephrine. The selective fi-agonists isoproterenol and salbutamol were ineffective at concentrations up to 10pM. 2. Stimulation of gluconeogenesis by 1IpM-adrenaline was almost completely blocked b...
Fluxes through intrahepatic glucose–producing metabolic pathways were measured in normal humans during overnight or prolonged (60 h) fasting. The glucuronate probe was used to measure the turnover and sources of hepatic UDP-glucose; mass isotopomer distribution analysis from [213 C 1 ]glycerol for gluconeogenesis and UDP-gluconeogenesis; [U13 C 6 ]glucose for glucose production (GP) and the dir...
Isolated rat kidneys were perfused with a cell-free perfusate, and their creatinine clearance was found to be 106 I'll min.1 g wet weight. Gluconeogenesis from pyruvate, lactate, fructose, a-oxoglutarate, oxaloacetate, glutamate and glutamine as the substrates at a concentration of 10 mM and ammonia production from glutamine were studied in the kidneys from fasted rats, rats with NH.CI-induced ...
1. Noradrenaline stimulates gluconeogenesis through an (a-adrenoceptor in renal cortical tubule fragments from fed rats incubated with 5 mM-lactate. 2. The selective a1-adrenoreceptor agonist methoxamine stimulated gluconeogenesis, but the selective a2-adrenoceptor agonist clonidine was ineffective. 3. The selective a1-adrenoceptor antagonist thymoxamine blocked the stimulatory effects on gluco...
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