Chitosan is a nontoxic, biodegradable, and biocompatible polysaccharide of b(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine. This derivative of natural chitin presents remarkable properties that have paved the way for the introduction of chitosan in the biomedical and pharmaceutical fields. Nevertheless, the properties of chitosan, such as its poor solubility in water or in organic solven...

Small molecular gelators are a class of compounds with potential applications for soft biomaterials. Low molecular weight hydrogelators are especially useful for exploring biomedical applications. Previously, we found that 4,6-O-benzylidene acetal protected D-glucose and D-glucosamine are well-suited as building blocks for the construction of low molecular weight gelators. To better understand ...

In this study a multicomponent reaction involving carbohydrate derivatives as the main component in order to prepare a new library of polyhydroxy compounds incorporating pyrimidine-fused heterocycles (PFHs) is introduced. A set of polyhydroxy functionalized PFHs were synthesized using multicomponent reactions of sugar (glucose, galactose, arabinose and lactose), barbituric acid and amines. Also...

The effects of hexosamines and their acetyl derivatives on the aggregation of 4-dimethylaminoazobenzene-induced rat hepatoma cells, dRLa-74 and dRLh-84, which have a low and high tumor-producing activity, respectively, were examined in rotation-mediated cell culture. D-Glucosamine, D-galactosamine, and D-mannosamine had relatively little effect on aggregation of either strain of hepatoma cells ...

The position of the O-sulfates in heparin was investigated by methylation procedures. Heparin was converted to the acetamido derivative and permethylated with diiethyl sulfate in aqueous alkali. Other methylation methods in organic solvents were also used. The carboxyl groups in the uranic acid moieties were then reduced and the resulting permethylated polysaccharide was hydrolyzed. The product...

The effects of hexosamines and their acetyl derivatives on the aggregation of 4-dimethylaminoazobenzene-induced rat hepatoma cells, dRLa-74 and dRLh-84, which have a low and high tumor-producing activity, respectively, were examined in rotation-mediated cell culture. D-Glucosamine, D-galactosamine, and D-mannosamine had relatively little effect on aggregation of either strain of hepatoma cells ...

background: degenerative joint disease (djd) is the most common joint disease in human beings. previous studies have explained that glucosamine is preferred as placebo and in efficacy compared with nsaid’s in treatment of patients’ knee osteoarthritis. alendronate was used to treat osteoporotic patients and its efficacy was established. objectives: the aim of this study was to compare the effic...