OBJECTIVE We examined the reliability of two continuous glucose sensors in type 1 diabetic patients at night and during rapid glucose excursions and verified the hypothesized nocturnal hypoglycemic drift of the needle-type sensor (CGMSgold) and delay of the microdialysis sensor (GlucoDay). RESEARCH DESIGN AND METHODS Blood was sampled overnight twice per hour in 13 patients. Rapid-acting insu...

Tight glycemic control slows or prevents the development of short- and long-term complications of diabetes mellitus. Continuous glucose measurements provide improved glycemic control and potentially prevent these diabetic complications. Glucose sensors, especially implantable devices, offer an alternative to classical self-monitored blood glucose levels and have shown promising glucose-sensing ...

An enzyme-metal-insulator-silicon (EMIS) structured chemical sensor based on photovoltage technology is constructed for potentiometric biosensing of glucose in a flow-injection analysis (FIA) system. To enhance the sensibility of the sensor to glucose, an ultra-thin (60 nm) film of polypyrrole (PPy)-glucose oxidase (GOD) is formed as the glucose-sensitive membrane through a simple electropolyme...

The core element of a continuous glucose monitoring (CGM) system is the glucose sensor, which should enable reliable CGM readings in the interstitial fluid in subcutaneous tissue for a period of several days. The aim of this article is to describe the layout and constituents of a novel glucose sensor and the rationale behind the measures that were used to optimize its performance. In order to a...

In this article, we report a functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose. To adjust the sensor for intracellular glucose measurements, we grew hexagonal ZnO nanorods on the tip of a silver-covered borosilicate glass capillary (0.7 microm diameter) and coated them with the enzyme glucose oxidase. The enzyme-coated ZnO nanorods exhibited a glucose-d...

This work updates the recent progress made toward fabricating a real-time, quantitative, and biocompatible glucose sensor based on surface-enhanced Raman scattering (SERS). The sensor design relies on an alkanethiolate tri(ethylene glycol) monolayer that acts as a partition layer, preconcentrating glucose near a SERS-active surface. Chemometric analysis of the captured SERS spectra demonstrates...

A soft contact-lens amperometric glucose sensor as novel non-invasive device of body sensor network was fabricated and tested. Also, the sensor was utilized to tear glucose monitoring. The sensor was constructed by immobilizing GOD onto a flexible oxygen electrode, which was fabricated using “Soft-MEMS” techniques onto a functional polymer membrane. In purpose of bioinstrumentation, adhesive ag...

BACKGROUND Self-monitoring of blood glucose (SMBG) is an important component of the modern therapy for diabetes mellitus. Thanks to the current progress in electronics and sensor fabrication technology, both the time and the blood sample volume required for the measurement have decreased drastically. However, devices that work with an even smaller sample volume and a shorter measurement time ar...