Several studies have shown that stress has major effects on metabolism. There is also some evidence indicating that stress may induce diabetes mellitus. The present study has investigated the role of chronic psychological stress on carbohydrate metabolism in male Wistar rats (250 ± 50 g). Animals were divided into control and test groups (n = 8/group). Blood samples were obtained by tail snippi...

introduction: many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. methods: pregnant rats were divided into the fetal hypothyroidism (fh) and the control (c) groups. ...

Current criteria for the diagnosis of diabetes c A1C $6.5%. The test should be performed in a laboratory using a method that is NGSP certified and standardized to the Diabetes Control and Complications Trial (DCCT) assay; or c fasting plasma glucose (FPG) $126 mg/dL (7.0 mmol/L). Fasting is defined as no caloric intake for at least 8 h; or c 2-h plasma glucose $200 mg/dL (11.1 mmol/L) during an...

Several studies have shown that stress has major effects on metabolism. There is also some evidence indicating that stress may induce diabetes mellitus. The present study has investigated the role of chronic psychological stress on carbohydrate metabolism in male Wistar rats (250 ± 50 g). Animals were divided into control and test groups (n = 8/group). Blood samples were obtained by tail snippi...

OBJECTIVE Impaired glucose effectiveness (GE) plays a role in the deterioration of glucose metabolism. Our aim was to validate a surrogate of GE derived from an oral glucose tolerance test (OGTT) and to assess the impact of degrees of obesity and of glucose tolerance on it. RESEARCH DESIGN AND METHODS The OGTT-derived surrogate of GE (oGE) was validated in obese adolescents who underwent an O...

Impaired glucose tolerance has several adverse effects on growing fetus. In this study we evaluated the effect of excessive weight gain during pregnancy on the risk of glucose intolerance in pregnant women. A case-control study was conducted through which the glucose tolerance status after 100 gram oral glucose intake was compared between 60 pregnant women with maximum 10 weeks of gestation and...

The ENGINE study evaluated noninvasive skin fluorescence spectroscopy (SFS) for detection of abnormal glucose tolerance (AGT). The AGT detection performance of SFS was compared to fasting plasma glucose (FPG) and hemoglobin A1C (A1C). The study was a head-to-head comparison of SFS to FPG and A1C in an at-risk population of 507 subjects, with no prior diagnosis of diabetes, each of whom received...

An account is given of asymptomatic diabetes mellitus. To determine the incidence in 200 patients with senile cataract 3 tests are described, namely, a modified standard glucose tolerance test, a provocative steroid glucose tolerance test, and a standard glucose tolerance test. Known diabetics and patients with a fasting blood glucose in excess of 5.5 mmol/l or glycosuria were excluded. Eighty-...

Chronic sleep curtailment in humans has been related to impairment of glucose metabolism. To better understand the underlying mechanisms, the purpose of the present study was to investigate the effect of acute sleep deprivation on glucose tolerance in rats. A group of rats was challenged by 4-h sleep deprivation in the early rest period, leading to prolonged (16 h) wakefulness. Another group of...